PLXNA4

PLXNA4 (Plexin A4) is a protein coding gene. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology annotations related to this gene include semaphorin receptor activity. An important paralog of the gene is PLXNA2.

Full Name

Plexin A4

Function

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Biological Process

Anterior commissure morphogenesisIEA:Ensembl
Chemorepulsion of branchiomotor axonIEA:Ensembl
Embryonic heart tube developmentIEA:Ensembl
Facial nerve structural organizationIEA:Ensembl
Glossopharyngeal nerve morphogenesisIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Postganglionic parasympathetic fiber developmentIEA:Ensembl
Regulation of axon extension involved in axon guidanceIEA:Ensembl
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of negative chemotaxisIEA:Ensembl
Semaphorin-plexin signaling pathway1 PublicationNAS:BHF-UCL
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Sympathetic nervous system developmentIEA:Ensembl
Sympathetic neuron axon guidanceIEA:Ensembl
Trigeminal nerve structural organizationIEA:Ensembl
Vagus nerve morphogenesisIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 24-1237
Helical: 1238-1258
Cytoplasmic: 1259-1894