Rabbit Anti-PLXNA4 Recombinant Antibody (C5D1) (CBMAB-P2201-YC)

Name: Rabbit Anti-PLXNA4 Recombinant Antibody (C5D1)
SKU: CBMAB-P2201-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

C5D1

Application

WB, IP

Specificity

Human, Rat, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Plexin A4

Introduction

PLXNA4 (Plexin A4) is a protein coding gene. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology annotations related to this gene include semaphorin receptor activity. An important paralog of the gene is PLXNA2.

Entrez Gene ID

Human	91584
Mouse	243743
Rat	312213

UniProt ID

Human	Q9HCM2
Mouse	Q80UG2
Rat	D3ZES7

Alternative Names

FAYV2820; PLEXA4; PLXNA4A; PLXNA4B; PRO34003

Function

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Biological Process

Anterior commissure morphogenesisIEA:Ensembl
Chemorepulsion of branchiomotor axonIEA:Ensembl
Embryonic heart tube developmentIEA:Ensembl
Facial nerve structural organizationIEA:Ensembl
Glossopharyngeal nerve morphogenesisIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Postganglionic parasympathetic fiber developmentIEA:Ensembl
Regulation of axon extension involved in axon guidanceIEA:Ensembl
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of negative chemotaxisIEA:Ensembl
Semaphorin-plexin signaling pathway1 PublicationNAS:BHF-UCL
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Sympathetic nervous system developmentIEA:Ensembl
Sympathetic neuron axon guidanceIEA:Ensembl
Trigeminal nerve structural organizationIEA:Ensembl
Vagus nerve morphogenesisIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 24-1237
Helical: 1238-1258
Cytoplasmic: 1259-1894

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PLXNA4 Recombinant Antibody (CBYC-P463) (CAT#: CBMAB-P2200-YC)

Mouse Anti-PLXNA4 Recombinant Antibody (MM087416T23) (CAT#: CBMAB-1670-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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