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Mouse Anti-PLXNA4 Recombinant Antibody (CBYC-P463) (CBMAB-P2200-YC)

Provided herein is a Mouse monoclonal antibody against Human Plexin A4. The antibody can be used for immunoassay techniques, such as FC.
See all PLXNA4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P463
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Plexin A4
Introduction
PLXNA4 (Plexin A4) is a protein coding gene. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology annotations related to this gene include semaphorin receptor activity. An important paralog of the gene is PLXNA2.
Entrez Gene ID
91584
UniProt ID
Q9HCM2
Alternative Names
FAYV2820; PLEXA4; PLXNA4A; PLXNA4B; PRO34003
Function
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Biological Process
Anterior commissure morphogenesisIEA:Ensembl
Chemorepulsion of branchiomotor axonIEA:Ensembl
Embryonic heart tube developmentIEA:Ensembl
Facial nerve structural organizationIEA:Ensembl
Glossopharyngeal nerve morphogenesisIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Postganglionic parasympathetic fiber developmentIEA:Ensembl
Regulation of axon extension involved in axon guidanceIEA:Ensembl
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of negative chemotaxisIEA:Ensembl
Semaphorin-plexin signaling pathway1 PublicationNAS:BHF-UCL
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Sympathetic nervous system developmentIEA:Ensembl
Sympathetic neuron axon guidanceIEA:Ensembl
Trigeminal nerve structural organizationIEA:Ensembl
Vagus nerve morphogenesisIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 24-1237
Helical: 1238-1258
Cytoplasmic: 1259-1894
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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