RECK

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Reversion Inducing Cysteine Rich Protein With Kazal Motifs

Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314).
Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).
Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314).
ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314).
Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466).
Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069).

Biological Process blood vessel maturationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process embryo implantationIEA:Ensembl
Biological Process embryonic forelimb morphogenesisIEA:Ensembl
Biological Process extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of metalloendopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of canonical Wnt signaling pathwayIEA:Ensembl
Biological Process regulation of angiogenesisIEA:Ensembl
Biological Process regulation of establishment of blood-brain barrierIEA:Ensembl
Biological Process sprouting angiogenesisManual Assertion Based On ExperimentIBA:GO_Central

Cell membrane

N-glycosylated.