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Rabbit Anti-RECK Recombinant Antibody (D8C7) (CBMAB-R2010-CN)

This product is a Rabbit antibody that recognizes RECK. The antibody D8C7 can be used for immunoassay techniques such as: WB.
See all RECK antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D8C7
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Reversion Inducing Cysteine Rich Protein With Kazal Motifs
Introduction
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Entrez Gene ID
Human8434
Mouse53614
Rat313488
Monkey694043
UniProt ID
HumanO95980
MouseQ9Z0J1
RatD4ABJ4
MonkeyF6Z6L8
Alternative Names
Reversion Inducing Cysteine Rich Protein With Kazal Motifs; Suppressor Of Tumorigenicity 15 Protein; ST15; Suppression Of Tumorigenicity 15 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs); Suppression Of Tumorigenicity 5 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs); Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs; Membrane-Anchored Glycoprotein (Metastasis And Invasion); HRECK;
Function
Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314).
Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).
Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314).
ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314).
Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466).
Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069).
Biological Process
Biological Process blood vessel maturationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process embryo implantationIEA:Ensembl
Biological Process embryonic forelimb morphogenesisIEA:Ensembl
Biological Process extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of metalloendopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of canonical Wnt signaling pathwayIEA:Ensembl
Biological Process regulation of angiogenesisIEA:Ensembl
Biological Process regulation of establishment of blood-brain barrierIEA:Ensembl
Biological Process sprouting angiogenesisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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