Mouse Anti-RECK Recombinant Antibody (32C10A) (CBMAB-R2008-CN)

Name: Mouse Anti-RECK Recombinant Antibody (32C10A)
SKU: CBMAB-R2008-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

32C10A

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

Reversion Inducing Cysteine Rich Protein With Kazal Motifs

Introduction

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Entrez Gene ID

8434

UniProt ID

O95980

Alternative Names

Reversion Inducing Cysteine Rich Protein With Kazal Motifs; Suppressor Of Tumorigenicity 15 Protein; ST15; Suppression Of Tumorigenicity 15 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs); Suppression Of Tumorigenicity 5 (Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs); Reversion-Inducing Cysteine-Rich Protein With Kazal Motifs; Membrane-Anchored Glycoprotein (Metastasis And Invasion); HRECK;

Function

Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314).
Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).
Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314).
ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314).
Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466).
Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069).

Biological Process

Biological Process blood vessel maturationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process embryo implantationIEA:Ensembl
Biological Process embryonic forelimb morphogenesisIEA:Ensembl
Biological Process extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of metalloendopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of canonical Wnt signaling pathwayIEA:Ensembl
Biological Process regulation of angiogenesisIEA:Ensembl
Biological Process regulation of establishment of blood-brain barrierIEA:Ensembl
Biological Process sprouting angiogenesisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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