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SYCP3

SYCP3 (Synaptonemal Complex Protein 3) is a protein coding gene. Diseases associated with SYCP3 include Spermatogenic Failure 4 and Azoospermia. Among its related pathways are Cell Cycle, Mitotic and Meiosis.

Full Name

Synaptonemal Complex Protein 3

Function

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity).
Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120).
Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).

Biological Process

Biological Process cell divisionIEA:UniProtKB-KW
Biological Process male meiosis INAS:UniProtKB1 Publication
Biological Process meiotic cell cycleIBA:GO_Central1 Publication
Biological Process spermatid developmentIBA:GO_Central1 Publication
Biological Process spermatogenesis, exchange of chromosomal proteinsIMP:UniProtKB1 Publication

Cellular Location

Nucleus
Chromosome
Chromosome, centromere
It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres.

Involvement in disease

Spermatogenic failure 4 (SPGF4):
An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes.
Pregnancy loss, recurrent, 4 (RPRGL4):
A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.

PTM

Phosphorylated.

Anti-SYCP3 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-SYCP3 Recombinant Antibody (Cor 10G11/7) (CBMAB-S6293-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Hamster, Zebrafish

Clone: Cor 10G11/7

Application*: WB, E, P, C, IF

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-2540) (CBMAB-S5296-CQ)

SDS

Target: SYCP3

Host: Mouse

Specificity: Human

Clone: CBXS-2540

Application*: E, F, IC, IH, WB

Rabbit Anti-SYCP3 Recombinant Antibody (CBXS-1329) (CBMAB-S4187-CQ)

SDS

Target: SYCP3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1329

Application*: WB, F

Mouse Anti-SYCP3 Recombinant Antibody (6F9C5) (CBMAB-S2886-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6F9C5

Application*: WB, F, E, IH, IF, P

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-5177) (CBMAB-S2395-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5177

Application*: WB

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-4952) (CBMAB-S2174-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4952

Application*: WB

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-4944) (CBMAB-S2166-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4944

Application*: WB

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-4849) (CBMAB-S2073-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4849

Application*: WB

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-4785) (CBMAB-S2011-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4785

Application*: WB

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-4587) (CBMAB-S1827-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4587

Application*: WB

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-4535) (CBMAB-S1775-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4535

Application*: WB

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-3858) (CBMAB-S1128-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3858

Application*: WB

Mouse Anti-SYCP3 Recombinant Antibody (CBXS-3796) (CBMAB-S1067-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3796

Application*: E, WB

Mouse Anti-SYCP3 (AA 27-128) Recombinant Antibody (CBXS-5830) (CBMAB-S0686-CQ)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5830

Application*: E, F, IC, P, WB

Mouse Anti-SYCP3 Recombinant Antibody (CBT2711) (V2LY-0625-LY54)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2711

Application*: IH, IC, F

Mouse Anti-SYCP3 Recombinant Antibody (CBT4456) (V2LY-0625-LY53)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT4456

Application*: IH, IC, F

Mouse Anti-SYCP3 Recombinant Antibody (CBT1124) (V2LY-0625-LY3017)

SDS

Target: SYCP3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBT1124

Application*: WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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