Sign in or Register   Sign in or Register
  |  

Mouse Anti-SYCP3 (AA 27-128) Recombinant Antibody (CBXS-5830) (CBMAB-S0686-CQ)

This product is a mouse antibody that recognizes SYCP3. The antibody CBXS-5830 can be used for immunoassay techniques such as: ELISA, FC, ICC, IHC-P, WB.
See all SYCP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5830
Antibody Isotype
IgG1
Application
ELISA, FC, ICC, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.5% protein stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 27-128

Target

Full Name
Synaptonemal Complex Protein 3
Introduction
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein.
Entrez Gene ID
50511
UniProt ID
Q8IZU3
Alternative Names
COR1; SCP3; SPGF4; RPRGL4
Function
Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity).
Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120).
Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).
Biological Process
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process male meiosis INAS:UniProtKB1 Publication
Biological Process meiotic cell cycleIBA:GO_Central1 Publication
Biological Process spermatid developmentIBA:GO_Central1 Publication
Biological Process spermatogenesis, exchange of chromosomal proteinsIMP:UniProtKB1 Publication
Cellular Location
Nucleus
Chromosome
Chromosome, centromere
It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres.
Involvement in disease
Spermatogenic failure 4 (SPGF4):
An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes.
Pregnancy loss, recurrent, 4 (RPRGL4):
A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.
PTM
Phosphorylated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SYCP3 (AA 27-128) Recombinant Antibody (CBXS-5830)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare