TGFB1I1

This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

TGFB1I1 Gene(Protein Coding) Transforming Growth Factor Beta 1 Induced Transcript 1

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.

Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process cell fate commitmentSource:Ensembl
Biological Process epithelial cell differentiationSource:Ensembl
Biological Process fat cell differentiationSource:Ensembl
Biological Process morphogenesis of embryonic epitheliumSource:Ensembl
Biological Process negative regulation of cell population proliferationSource:ProtInc1 Publication
Biological Process negative regulation of fat cell differentiationSource:Ensembl
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process ubiquitin-dependent SMAD protein catabolic processSource:BHF-UCL1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW

Cell junction, focal adhesion
Nucleus matrix
Cytoplasm, cytoskeleton
Associated with the actin cytoskeleton; colocalizes with stress fibers.

Phosphorylated by gonadotropin-releasing hormone-activated SRC.