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Mouse Anti-TGFB1I1 Recombinant Antibody (CBFYH-2791) (CBMAB-H3860-FY)

This product is mouse antibody that recognizes TGFB1I1. The antibody CBFYH-2791 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all TGFB1I1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYH-2791
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TGFB1I1 Gene(Protein Coding) Transforming Growth Factor Beta 1 Induced Transcript 1
Introduction
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human7041
Mouse21804
Rat84574
UniProt ID
HumanO43294
MouseQ62219
RatQ99PD6
Alternative Names
Transforming Growth Factor Beta 1 Induced Transcript 1; Androgen Receptor-Associated Protein Of 55 KDa; Androgen Receptor Coactivator 55 KDa Protein; Hydrogen Peroxide-Inducible Clone 5 Protein; Hydrogen Peroxide-Inducible Clone-5; HIC-5
Function
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
Biological Process
Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process cell fate commitmentSource:Ensembl
Biological Process epithelial cell differentiationSource:Ensembl
Biological Process fat cell differentiationSource:Ensembl
Biological Process morphogenesis of embryonic epitheliumSource:Ensembl
Biological Process negative regulation of cell population proliferationSource:ProtInc1 Publication
Biological Process negative regulation of fat cell differentiationSource:Ensembl
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process ubiquitin-dependent SMAD protein catabolic processSource:BHF-UCL1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Cell junction, focal adhesion
Nucleus matrix
Cytoplasm, cytoskeleton
Associated with the actin cytoskeleton; colocalizes with stress fibers.
PTM
Phosphorylated by gonadotropin-releasing hormone-activated SRC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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