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Mouse Anti-TGFB1I1 Recombinant Antibody (4B2-D8) (CBMAB-A4853-YC)

Provided herein is a Mouse monoclonal antibody against Human Transforming Growth Factor Beta 1 Induced Transcript 1. The antibody can be used for immunoassay techniques, such as ELISA, RNAi, WB.
See all TGFB1I1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B2-D8
Antibody Isotype
IgG1, κ
Application
ELISA, RNAi, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TGFB1I1 Gene(Protein Coding) Transforming Growth Factor Beta 1 Induced Transcript 1
Introduction
TGFB1I1 is a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play i
Entrez Gene ID
7041
UniProt ID
O43294
Alternative Names
Transforming Growth Factor Beta 1 Induced Transcript 1; Androgen Receptor-Associated Protein Of 55 KDa; Androgen Receptor Coactivator 55 KDa Protein; Hydrogen Peroxide-Inducible Clone 5 Protein; Hydrogen Peroxide-Inducible Clone-5; HIC-5;
Function
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
Biological Process
Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process cell fate commitmentSource:Ensembl
Biological Process epithelial cell differentiationSource:Ensembl
Biological Process fat cell differentiationSource:Ensembl
Biological Process morphogenesis of embryonic epitheliumSource:Ensembl
Biological Process negative regulation of cell population proliferationSource:ProtInc1 Publication
Biological Process negative regulation of fat cell differentiationSource:Ensembl
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwaySource:BHF-UCL1 Publication
Biological Process ubiquitin-dependent SMAD protein catabolic processSource:BHF-UCL1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Cell junction, focal adhesion
Nucleus matrix
Cytoplasm, cytoskeleton
Associated with the actin cytoskeleton; colocalizes with stress fibers.
PTM
Phosphorylated by gonadotropin-releasing hormone-activated SRC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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