TRADD

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

TRADD Gene(Protein Coding) TNFRSF1A Associated Via Death Domain

Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:7758105, PubMed:8612133, PubMed:23955153).
Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133).
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).

Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process cellular response to tumor necrosis factor Source:ARUK-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptors Source:BHF-UCL1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:ARUK-UCL1 Publication
Biological Process positive regulation of hair follicle development Source:Ensembl
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:ARUK-UCL1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:ARUK-UCL1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:ARUK-UCL1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:BHF-UCL1 Publication

Nucleus
Cytoplasm
Cytoplasm, cytoskeleton
Shuttles between the cytoplasm and the nucleus.

(Microbial infection) Glycosylated at Arg-235 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium proteins Ssek1 and Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNFRSF1A/TNFR1 complex, thereby disrupting TNF signaling.