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Rabbit Anti-TRADD Recombinant Antibody (CBYJT-4479) (CBMAB-T3982-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TRADD (TNFRSF1A Associated Via Death Domain). The antibody can be used for immunoassay techniques, such as IP, WB.
See all TRADD antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJT-4479
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding glycine 227 of human TRADD
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
10 mM HEPES, 150 mM NaCl, pH 7.5, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Residues surrounding Gly227

Target

Full Name
TRADD Gene(Protein Coding) TNFRSF1A Associated Via Death Domain
Introduction
TRADD is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. TRADD binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. TRADD can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
Entrez Gene ID
8717
UniProt ID
Q15628
Alternative Names
TNFRSF1A Associated Via Death Domain; TNFRSF1A-Associated Via Death Domain; Tumor Necrosis Factor Receptor Type 1 Associated Death Domain Protein; Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein; Tumor Necrosis Factor Receptor-1-Associated Protein; TNFR1-Associated Death Domain Protein; TNFR1-Associated DEATH Domain Protein; Hs.89862
Function
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:7758105, PubMed:8612133, PubMed:23955153).
Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133).
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).
Biological Process
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process cellular response to tumor necrosis factor Source:ARUK-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptors Source:BHF-UCL1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:ARUK-UCL1 Publication
Biological Process positive regulation of hair follicle development Source:Ensembl
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:ARUK-UCL1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:ARUK-UCL1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:ARUK-UCL1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:BHF-UCL1 Publication
Cellular Location
Nucleus
Cytoplasm
Cytoplasm, cytoskeleton
Shuttles between the cytoplasm and the nucleus.
PTM
(Microbial infection) Glycosylated at Arg-235 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium proteins Ssek1 and Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNFRSF1A/TNFR1 complex, thereby disrupting TNF signaling.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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