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Mouse Anti-TRADD Recombinant Antibody (CBT4457) (V2LY-0625-LY1241)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4457
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human TRADD (AA: 1-177) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TRADD Gene(Protein Coding) TNFRSF1A Associated Via Death Domain
Entrez Gene ID
8717
Function
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:7758105, PubMed:8612133, PubMed:23955153).
Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133).
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).
Biological Process
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process cellular response to tumor necrosis factor Source:ARUK-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptors Source:BHF-UCL1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:ARUK-UCL1 Publication
Biological Process positive regulation of hair follicle development Source:Ensembl
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:ARUK-UCL1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:ARUK-UCL1 Publication
Biological Process positive regulation of NIK/NF-kappaB signaling Source:ARUK-UCL1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:BHF-UCL1 Publication
Cellular Location
Nucleus
Cytoplasm
Cytoplasm, cytoskeleton
Shuttles between the cytoplasm and the nucleus.
PTM
(Microbial infection) Glycosylated at Arg-235 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium proteins Ssek1 and Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNFRSF1A/TNFR1 complex, thereby disrupting TNF signaling.
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For research use only. Not intended for any clinical use.

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