BNIP1

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq]

Full Name

BCL2/adenovirus E1B 19kDa interacting protein 1

Function

As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311).
Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122).
It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122).
As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).

Biological Process

Apoptotic process Source: MGI
Endoplasmic reticulum membrane fusion Source: HGNC-UCL
Endoplasmic reticulum organization Source: HGNC-UCL
Execution phase of apoptosis Source: BHF-UCL
Negative regulation of apoptotic process Source: UniProtKB
Response to activity Source: Ensembl
Response to oxygen-glucose deprivation Source: Ensembl
Response to starvation Source: Ensembl
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Viral process Source: UniProtKB-KW

Cellular Location

Endoplasmic reticulum membrane; Mitochondrion membrane. Localization to the mitochondrion is regulated by RNF186.

Topology

Cytoplasmic: 1-199 aa
Helical: 200-220 aa
Lumenal: 221-228 aa

PTM

Polyubiquitinated (PubMed:21931693, PubMed:23896122). 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1 (PubMed:21931693). Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion (PubMed:23896122).