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Rabbit Anti-BNIP1 Recombinant Antibody (CBYY-0702) (CBMAB-0705-YY)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBYY-0702
Antibody Isotype
IgG
Application
WB, IH

Basic Information

Immunogen
A synthesized peptide derived from human BNIP1.
Host Species
Rabbit
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol, 0.4-0.5mg/ml BSA
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BCL2/adenovirus E1B 19kDa interacting protein 1
Introduction
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini.
Entrez Gene ID
Human662
Mouse224630
Rat140932
UniProt ID
HumanQ12981
MouseQ6QD59
RatQ8VHI8
Alternative Names
BCL2 Interacting Protein 1; BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 1; BCL2/Adenovirus E1B 19kDa Interacting Protein 1; Transformation-Related Gene 8 Protein; TRG-8; NIP1; Vesicle Transport Protein SEC20; SEC20L; SEC20;
Function
As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311).
Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122).
It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122).
As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).
Biological Process
Apoptotic process Source: MGI
Endoplasmic reticulum membrane fusion Source: HGNC-UCL
Endoplasmic reticulum organization Source: HGNC-UCL
Execution phase of apoptosis Source: BHF-UCL
Negative regulation of apoptotic process Source: UniProtKB
Response to activity Source: Ensembl
Response to oxygen-glucose deprivation Source: Ensembl
Response to starvation Source: Ensembl
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Viral process Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Mitochondrion membrane. Localization to the mitochondrion is regulated by RNF186.
Topology
Cytoplasmic: 1-199 aa
Helical: 200-220 aa
Lumenal: 221-228 aa
PTM
Polyubiquitinated (PubMed:21931693, PubMed:23896122). 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1 (PubMed:21931693). Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion (PubMed:23896122).
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For research use only. Not intended for any clinical use.

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