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Mouse Anti-BNIP1 Recombinant Antibody (1G7) (CBMAB-A0842-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G7
Antibody Isotype
IgG2a, κ
Application
WB, E, IF

Basic Information

Immunogen
BNIP1 (AAH10959, 1 a.a. ~ 228 a.a) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BCL2/adenovirus E1B 19kDa interacting protein 1
Introduction
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq]
Entrez Gene ID
662
UniProt ID
Q12981
Alternative Names
NIP1; SEC20; TRG-8
Function
As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311).
Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122).
It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122).
As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).
Biological Process
Apoptotic process Source: MGI
Endoplasmic reticulum membrane fusion Source: HGNC-UCL
Endoplasmic reticulum organization Source: HGNC-UCL
Execution phase of apoptosis Source: BHF-UCL
Negative regulation of apoptotic process Source: UniProtKB
Response to activity Source: Ensembl
Response to oxygen-glucose deprivation Source: Ensembl
Response to starvation Source: Ensembl
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Viral process Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Mitochondrion membrane. Localization to the mitochondrion is regulated by RNF186.
Topology
Cytoplasmic: 1-199 aa
Helical: 200-220 aa
Lumenal: 221-228 aa
PTM
Polyubiquitinated (PubMed:21931693, PubMed:23896122). 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1 (PubMed:21931693). Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion (PubMed:23896122).
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For research use only. Not intended for any clinical use.

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