Sign in or Register   Sign in or Register
  |  

Mouse Anti-BNIP1 Recombinant Antibody (1G7) (CBMAB-A0842-LY)

The product is antibody recognizes BNIP1. The antibody 1G7 immunoassay techniques such as: WB, ELISA.
See all BNIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
BNIP1 (AAH10959, 1 a.a. ~ 228 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BCL2/adenovirus E1B 19kDa interacting protein 1
Introduction
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq]
Entrez Gene ID
662
UniProt ID
Q12981
Alternative Names
NIP1; SEC20; TRG-8
Function
As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311).
Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122).
It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122).
As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).
Biological Process
Apoptotic process Source: MGI
Endoplasmic reticulum membrane fusion Source: HGNC-UCL
Endoplasmic reticulum organization Source: HGNC-UCL
Execution phase of apoptosis Source: BHF-UCL
Negative regulation of apoptotic process Source: UniProtKB
Response to activity Source: Ensembl
Response to oxygen-glucose deprivation Source: Ensembl
Response to starvation Source: Ensembl
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Viral process Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Mitochondrion membrane. Localization to the mitochondrion is regulated by RNF186.
Topology
Cytoplasmic: 1-199 aa
Helical: 200-220 aa
Lumenal: 221-228 aa
PTM
Polyubiquitinated (PubMed:21931693, PubMed:23896122). 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1 (PubMed:21931693). Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion (PubMed:23896122).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-BNIP1 Recombinant Antibody (1G7)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare