CFTR

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]
Full Name
Cystic Fibrosis Transmembrane Conductance Regulator
Function
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
Biological Process
Chloride transport Source: UniProtKB-KW
Cellular Location
Early endosome membrane; Endosome membrane; Recycling endosome membrane; Apical cell membrane; Cell membrane; Endoplasmic reticulum membrane; Nucleus
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Anti-CFTR antibodies

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Mouse Anti-CFTR Recombinant Antibody (CBXC-0391) (CBMAB-C4393-CQ)

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Target: CFTR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0391
Application*: P
Datasheet SDS

Mouse Anti-CFTR Recombinant Antibody (CBXC-0393) (CBMAB-C4392-CQ)

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Target: CFTR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0393
Application*: P
Datasheet SDS

Rabbit Anti-CFTR Recombinant Antibody (CBXC-0969) (CBMAB-C1231-CQ)

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Target: CFTR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-0969
Application*: P
Datasheet SDS

Rabbit Anti-CFTR Recombinant Antibody (C0553) (CBMAB-C0553-CQ)

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Target: CFTR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C0553
Application*: P
Datasheet SDS

Mouse Anti-CFTR Recombinant Antibody (CBYY-C1925) (CBMAB-C3363-YY)

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Target: CFTR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C1925
Application*: IF, P
Datasheet SDS

Mouse Anti-CFTR Recombinant Antibody (CBYY-C1924) (CBMAB-C3362-YY)

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Target: CFTR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBYY-C1924
Application*: P
Datasheet SDS

Mouse Anti-CFTR Recombinant Antibody (CBFYC-1777) (CBMAB-C1839-FY)

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Target: CFTR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1777
Application*: IF, IP, WB, P
Datasheet SDS

Mouse Anti-CFTR Recombinant Antibody (CBFYC-1776) (CBMAB-C1838-FY)

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Target: CFTR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1776
Application*: E, IF, IP, WB, P
Datasheet SDS

Rat Anti-CFTR Recombinant Antibody (CBFYM-0994) (CBMAB-M1145-FY)

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Target: CFTR
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: Supernatant
Application*: WB, IH, IF, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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