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CFTR

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]

Full Name

Cystic Fibrosis Transmembrane Conductance Regulator

Function

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.

Biological Process

Chloride transport Source: UniProtKB-KW

Cellular Location

Early endosome membrane; Endosome membrane; Recycling endosome membrane; Apical cell membrane; Cell membrane; Endoplasmic reticulum membrane; Nucleus

Anti-CFTR antibodies

Mouse Anti-CFTR Recombinant Antibody (CF3) (CBMAB-0225CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Mouse, Chicken, Rat

Clone: CF3

Application*: BL, F, IF, IH, P, IP, WB

Rat Anti-CFTR Recombinant Antibody (CBFYM-0994) (CBMAB-M1145-FY)

SDS

Target: CFTR

Host: Rat

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-0994

Application*: WB, IH, IC

Mouse Anti-CFTR Recombinant Antibody (L12B4) (CBMAB-C3630WJ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: L12B4

Application*: IF, P, IP

Mouse Anti-CFTR Recombinant Antibody (CBWJC-2548) (CBMAB-C3629WJ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-2548

Application*: WB

Mouse Anti-CFTR Recombinant Antibody (CBWJC-2547) (CBMAB-C3628WJ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJC-2547

Application*: F, P, WB

Rabbit Anti-CFTR Recombinant Antibody (D6W6L) (CBMAB-CP0286-LY)

SDS

Target: CFTR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D6W6L

Application*: WB, IP, IF (IC)

Mouse Anti-CFTR (AA 1377-1480) Recombinant Antibody (CBFYC-1776) (CBMAB-C1838-FY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-1776

Application*: WB, IH, IP

Mouse Anti-CFTR Recombinant Antibody (CBFYC-1777) (CBMAB-C1839-FY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1777

Application*: WB, IH, IP, IF

Mouse Anti-CFTR Recombinant Antibody (CFTR/1341) (CBMAB-C0549-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CFTR/1341

Application*: WB, IF, P

Mouse Anti-CFTR Recombinant Antibody (CFTR/1342) (CBMAB-C0550-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CFTR/1342

Application*: WB, F, P, IF

Mouse Anti-CFTR Recombinant Antibody (CFTR/1643) (CBMAB-C0551-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CFTR/1643

Application*: IF, P

Mouse Anti-CFTR Recombinant Antibody (CFTR/1644) (CBMAB-C0552-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CFTR/1644

Application*: E, IF

Rabbit Anti-CFTR Recombinant Antibody (CFTR/1775R) (CBMAB-C0553-CQ)

SDS

Target: CFTR

Host: Rabbit

Antibody Isotype: IgG, κ

Specificity: Human

Clone: CFTR/1775R

Application*: IF, P

Mouse Anti-CFTR Recombinant Antibody (SPM176) (CBMAB-C1072-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: SPM176

Application*: WB, IF, P

Mouse Anti-CFTR Recombinant Antibody (CBXC-0969) (CBMAB-C1231-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0969

Application*: WB, IH, IP, IF

Mouse Anti-CFTR Recombinant Antibody (GA1) (CBMAB-C4390-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: GA1

Application*: WB

Mouse Anti-CFTR Recombinant Antibody (CFTR1-1) (CBMAB-C4391-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CFTR1-1

Application*: F, P, WB

Mouse Anti-CFTR Recombinant Antibody (CBXC-0393) (CBMAB-C4392-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-0393

Application*: IF, IH, IP, WB

Mouse Anti-CFTR Recombinant Antibody (CBXC-0391) (CBMAB-C4393-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0391

Application*: IF, IP, WB

Mouse Anti-CFTR Recombinant Antibody (CBXC-0394) (CBMAB-C4395-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-0394

Application*: IH, IP, WB

Mouse Anti-CFTR Recombinant Antibody (CBXC-0395) (CBMAB-C4396-CQ)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-0395

Application*: IC, P, IP, WB

Mouse Anti-CFTR Recombinant Antibody (13-1) (CBMAB-C2703-LY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13-1

Application*: WB, IH, IP, IF

Mouse Anti-CFTR Recombinant Antibody (24-1) (CBMAB-C4466-LY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 24-1

Application*: WB, IH, IP

Mouse Anti-CFTR Recombinant Antibody (2Q2295) (CBMAB-C5352-LY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2Q2295

Application*: IF, IH, IP, WB

Mouse Anti-CFTR Recombinant Antibody (2Q999) (CBMAB-C5415-LY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2Q999

Application*: E, WB, IP, IC

Mouse Anti-CFTR Recombinant Antibody (3F140) (CBMAB-C6019-LY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 3F140

Application*: IF, IP, WB

Mouse Anti-CFTR Recombinant Antibody (4i35) (CBMAB-C7099-LY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4i35

Application*: E, WB, IP, IH

Mouse Anti-CFTR Recombinant Antibody (CBYY-C1924) (CBMAB-C3362-YY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBYY-C1924

Application*: IF, IP, WB

Mouse Anti-CFTR Recombinant Antibody (CBYY-C1925) (CBMAB-C3363-YY)

SDS

Target: CFTR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1925

Application*: E, WB, IP, IH

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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