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Mouse Anti-CFTR Recombinant Antibody (CBYY-C1925) (CBMAB-C3363-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1925
Antibody Isotype
IgG2b, κ
Application
IF, IHC-P

Basic Information

Immunogen
Recombinant fragment (around aa 258-385) of human CFTR protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P1-2 μg/ml
FC1-2 μg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cystic Fibrosis Transmembrane Conductance Regulator
Entrez Gene ID
1080
UniProt ID
P13569
Alternative Names
T-Complex 1; TCP-1-Alpha; CCT-Alpha; CCTA; CCT1; T-Complex Protein 1, Alpha Subunit;
Function
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
Biological Process
Chloride transport Source: UniProtKB-KW
Cellular Location
Early endosome membrane; Endosome membrane; Recycling endosome membrane; Apical cell membrane; Cell membrane; Endoplasmic reticulum membrane; Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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