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Mouse Anti-CFTR Recombinant Antibody (CBFYC-1776) (CBMAB-C1838-FY)


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Published Data
CBMAB-C1838-FY-1
Mouse Anti-CFTR Recombinant Antibody (CBFYC-1776) (CBMAB-C1838-FY) in IHC
Structure of the rat vaginal epithelium and CFTR protein localization in the rat vaginal tissue following a two-week administration of Gelam honey at 0.2 g Gelam honey/kg bw/day doses. (A) Gelam honey and bilateral oophorectomized group (Gelam honey +Ovx), (B) Estrogen replacement therapy and bilateral oophorectomized group (ERT+Ovx), (C) Bilateral oophorectomized group (Ovx) and (D) Sham group (SC). The tissues were stained with DAB/HRP stain for protein localization (in brown) and counterstained with H&E for nuclear staining. All measurement bars are equivalent to 100 µm. ...View More
Ismail, N. H., Ibrahim, S. F., Mokhtar, M. H., Yahaya, A., Zulkefli, A. F., Ankasha, S. J., & Osman, K. (2023). Modulation of vulvovaginal atrophy (VVA) by Gelam honey in bilateral oophorectomized rats. Frontiers in Endocrinology, 14, 1031066.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1838-FY-2
Mouse Anti-CFTR Recombinant Antibody (CBFYC-1776) (CBMAB-C1838-FY) in WB
Western Blot analysis of CFTR (top) at low and high exposure and ACTB (bottom) on 16HBE14o- not exposed (CAC) or CNP-exposed from lane 2 to 9 representing different biological replicates. ...View More
Stermann, T., Nguyen, T., Stahlmecke, B., Todea, A. M., Woeste, S., Hacheney, I., ... & Rossi, A. (2022). Carbon nanoparticles adversely affect CFTR expression and toxicologically relevant pathways. Scientific Reports, 12(1), 14255.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1838-FY-3
Mouse Anti-CFTR Recombinant Antibody (CBFYC-1776) (CBMAB-C1838-FY) in IF
Fluorescence labeling of CFTR (green) and N protein (red) in BEAS-2B cells with DAPI-labeled nuclei (blue) after stimulation with N protein (50 μg/ml) for 24 h. Scale bars, 10 μm. ...View More
Chen, L., Guan, W. J., Qiu, Z. E., Xu, J. B., Bai, X., Hou, X. C., ... & Zhang, Y. L. (2022). SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl− accumulation in respiratory epithelium. Signal Transduction and Targeted Therapy, 7(1), 255.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1838-FY-4
Mouse Anti-CFTR Recombinant Antibody (CBFYC-1776) (CBMAB-C1838-FY) in WB
The effect of Inh miR-145 (100 nM) on the expression of CFTR in BEAS-2B cells stimulated by N protein (50 μg/ml) for 24 h, with the gray value analysis (n = 3). ...View More
Chen, L., Guan, W. J., Qiu, Z. E., Xu, J. B., Bai, X., Hou, X. C., ... & Zhang, Y. L. (2022). SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl− accumulation in respiratory epithelium. Signal Transduction and Targeted Therapy, 7(1), 255.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-1776
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IP, WB, IHC-P

Basic Information

Immunogen
Amino acids 1419-1457 near the C-terminus of CFTR of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1377-1480

Target

Full Name
Cystic Fibrosis Transmembrane Conductance Regulator
Introduction
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome.
Entrez Gene ID
1080
UniProt ID
P13569
Alternative Names
Cystic Fibrosis Transmembrane Conductance Regulator; Channel Conductance-Controlling ATPase; CAMP-Dependent Chloride Channel; EC 3.6.3.49; ABCC7; Cystic Fibrosis Transmembrane Conductance Regulator, ATP-Binding Cassette (Sub-Family C, Member 7); Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7); Cystic Fibrosis Transmembrane Conductance Regulating; ATP-Binding Cassette Sub-Family C, Member 7
Function
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
Biological Process
Chloride transport Source: UniProtKB-KW
Cellular Location
Early endosome membrane; Endosome membrane; Recycling endosome membrane; Apical cell membrane; Cell membrane; Endoplasmic reticulum membrane; Nucleus
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For research use only. Not intended for any clinical use.

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