COMT

COMT (Catechol-O-Methyltransferase) is a Protein Coding gene. Diseases associated with COMT include Schizophrenia and Panic Disorder 1. Among its related pathways are Cytochrome P450 - arranged by substrate type and Neurotransmitter Clearance In The Synaptic Cleft. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and catechol O-methyltransferase activity. An important paralog of this gene is LRTOMT.
Full Name
Catechol-O-Methyltransferase
Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Biological Process
Catecholamine catabolic process Source: UniProtKB
Developmental process Source: GO_Central
Dopamine metabolic process Source: GO_Central
Methylation Source: UniProtKB
Neurotransmitter catabolic process Source: UniProtKB-KW
Cellular Location
Isoform Soluble: Cytoplasm
Isoform Membrane-bound: Cell membrane
Involvement in disease
Schizophrenia (SCZD):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Topology
Cytoplasmic: 1-6
Helical: 7-26
Extracellular: 27-271
PTM
The N-terminus is blocked.
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Anti-COMT antibodies

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Rabbit Anti-COMT Recombinant Antibody (C0737) (CBMAB-C0737-CN)

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Target: COMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C0737
Application*: IH, WB
Datasheet SDS

Mouse Anti-COMT Recombinant Antibody (C0561) (CBMAB-C0561-CN)

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Target: COMT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: C0561
Application*: WB, IF, P
Datasheet SDS

Rabbit Anti-COMT Recombinant Antibody (
8E1) (V2LY-0725-LY1459)

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Target: COMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 8E1
Application*: E, WB, IH
Datasheet SDS

Rabbit Anti-COMT Recombinant Antibody (CBWJC-2950) (V2LY-1206-LY746)

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Target: COMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBWJC-2950
Application*: WB
Datasheet SDS

Mouse Anti-COMT Recombinant Antibody (CBYY-C2989) (V2LY-1206-LY745)

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Target: COMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBYY-C2989
Application*: WB, P, IF, F
Datasheet SDS

Mouse Anti-COMT Recombinant Antibody (CBFYC-2096) (V2LY-1206-LY744)

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Target: COMT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-2096
Application*: E, WB
Datasheet SDS

Mouse Anti-COMT Recombinant Antibody (C2200) (V2LY-1206-LY743)

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Target: COMT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: C2200
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-COMT Recombinant Antibody (1413) (V2LY-1206-LY742)

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Target: COMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1413
Application*: WB, P, E
Datasheet SDS

COMT Matched Antibody Pair (291) (APMAB-291LY)

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Target: COMT
Specificity: Human
Datasheet SDS

COMT Matched Antibody Pair (290) (APMAB-290LY)

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Target: COMT
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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