Rabbit Anti-COMT Recombinant Antibody (1413) (V2LY-1206-LY742)

Name: Rabbit Anti-COMT Recombinant Antibody (1413)
SKU: V2LY-1206-LY742
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

1413

Application

WB, IHC-P, ELISA

Immunogen

A synthesized peptide derived from human COMT.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC-P	1:50-1:200
WB	1:500-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% sodium azide

Concentration

2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Catechol-O-Methyltransferase

Entrez Gene ID

1312

UniProt ID

P21964

Function

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Biological Process

Catecholamine catabolic process Source: UniProtKB
Developmental process Source: GO_Central
Dopamine metabolic process Source: GO_Central
Methylation Source: UniProtKB
Neurotransmitter catabolic process Source: UniProtKB-KW

Cellular Location

Isoform Soluble: Cytoplasm
Isoform Membrane-bound: Cell membrane

Involvement in disease

Schizophrenia (SCZD):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

Topology

Cytoplasmic: 1-6
Helical: 7-26
Extracellular: 27-271

PTM

The N-terminus is blocked.

Sprague, B. N., Rosso, A. L., Zhu, X., Bohnen, N. I., & Rosano, C. (2021). Catechol‐O‐methyltransferase (COMT) polymorphism predicts rapid gait speed changes in healthy older adults. Journal of the American Geriatrics Society, 69(11), 3194-3202.

Cao, C., Cao, L., & Chen, J. (2019). Differences in sensitivity to environment depending on Catechol-O-Methyltransferase (COMT) gene? A meta-analysis of child and adolescent gene-by-environment studies. Journal of Youth and Adolescence, 48(4), 655-667.

Nogueira, N. G., Fernandes, L. A., Ferreira, B. P., Batista, M. T., Alves, K. C., & Parma, J. O. (2019). Association between the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism and manual performance asymmetries. Perceptual and Motor Skills, 126(3), 349-365.

Nogueira, N. G. D. H. M., Bacelar, M. F. B., de Paula Ferreira, B., Parma, J. O., & Lage, G. M. (2019). Association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and motor behavior in healthy adults: a study review. Brain Research Bulletin, 144, 223-232.

Satterfield, B. C., Hinson, J. M., Whitney, P., Schmidt, M. A., Wisor, J. P., & Van Dongen, H. P. (2018). Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation. Cortex, 99, 179-186.

Patel, C. N., Georrge, J. J., Modi, K. M., Narechania, M. B., Patel, D. P., Gonzalez, F. J., & Pandya, H. A. (2018). Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics, 36(15), 3938-3957.

Parkin, G. M., Udawela, M., Gibbons, A., Scarr, E., & Dean, B. (2018). Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex. Journal of human genetics, 63(12), 1251-1258.

Lin, C. H., Chaudhuri, K., Fan, J. Y., Ko, C. I., Rizos, A., Chang, C. W., ... & Wu, Y. R. (2017). Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease. Scientific reports, 7(1), 1-10.

Bastos, P., Gomes, T., & Ribeiro, L. (2017). Catechol-O-methyltransferase (COMT): an update on its role in cancer, neurological and cardiovascular diseases. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173, 1-39.

Matsuzaka, C. T., Christofolini, D., Ota, V. K., Gadelha, A., Berberian, A. A., Noto, C., ... & Bressan, R. A. (2017). Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls. Brazilian Journal of Psychiatry, 39, 302-308.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

COMT Matched Antibody Pair (290) (CAT#: APMAB-290LY)

COMT Matched Antibody Pair (291) (CAT#: APMAB-291LY)

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Isotype control

For research use only. Not intended for any clinical use.

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