COMT Matched Antibody Pair (290) (APMAB-290LY)

Name: COMT Matched Antibody Pair (290)
SKU: APMAB-290LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-COMT polyclonal antibody, 100 ug

Detection Antibody

Anti-COMT Mouse monoclonal, IgG2b antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

COMT (Catechol-O-Methyltransferase) is a Protein Coding gene. Diseases associated with COMT include Schizophrenia and Panic Disorder 1. Among its related pathways are Cytochrome P450 - arranged by substrate type and Neurotransmitter Clearance In The Synaptic Cleft. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and catechol O-methyltransferase activity. An important paralog of this gene is LRTOMT.

Alternative Names

Catechol-O-Methyltransferase; EC 2.1.1.6; Epididymis Secretory Sperm Binding Protein Li 98n; Catechol-O-Methyltransferase Isoform; Testicular Tissue Protein Li 42; Catechol O-Methyltransferase; HEL-S-98n;

Entrez Gene ID

1312

UniProt ID

P21964

More Infomation

Sprague, B. N., Rosso, A. L., Zhu, X., Bohnen, N. I., & Rosano, C. (2021). Catechol‐O‐methyltransferase (COMT) polymorphism predicts rapid gait speed changes in healthy older adults. Journal of the American Geriatrics Society, 69(11), 3194-3202.

Cao, C., Cao, L., & Chen, J. (2019). Differences in sensitivity to environment depending on Catechol-O-Methyltransferase (COMT) gene? A meta-analysis of child and adolescent gene-by-environment studies. Journal of Youth and Adolescence, 48(4), 655-667.

Nogueira, N. G., Fernandes, L. A., Ferreira, B. P., Batista, M. T., Alves, K. C., & Parma, J. O. (2019). Association between the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism and manual performance asymmetries. Perceptual and Motor Skills, 126(3), 349-365.

Nogueira, N. G. D. H. M., Bacelar, M. F. B., de Paula Ferreira, B., Parma, J. O., & Lage, G. M. (2019). Association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and motor behavior in healthy adults: a study review. Brain Research Bulletin, 144, 223-232.

Satterfield, B. C., Hinson, J. M., Whitney, P., Schmidt, M. A., Wisor, J. P., & Van Dongen, H. P. (2018). Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation. Cortex, 99, 179-186.

Patel, C. N., Georrge, J. J., Modi, K. M., Narechania, M. B., Patel, D. P., Gonzalez, F. J., & Pandya, H. A. (2018). Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics, 36(15), 3938-3957.

Parkin, G. M., Udawela, M., Gibbons, A., Scarr, E., & Dean, B. (2018). Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex. Journal of human genetics, 63(12), 1251-1258.

Lin, C. H., Chaudhuri, K., Fan, J. Y., Ko, C. I., Rizos, A., Chang, C. W., ... & Wu, Y. R. (2017). Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease. Scientific reports, 7(1), 1-10.

Bastos, P., Gomes, T., & Ribeiro, L. (2017). Catechol-O-methyltransferase (COMT): an update on its role in cancer, neurological and cardiovascular diseases. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173, 1-39.

Matsuzaka, C. T., Christofolini, D., Ota, V. K., Gadelha, A., Berberian, A. A., Noto, C., ... & Bressan, R. A. (2017). Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls. Brazilian Journal of Psychiatry, 39, 302-308.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

COMT Matched Antibody Pair (291) (CAT#: APMAB-291LY)

Antibody Pairs

COMT Matched Antibody Pair (291) (CAT#: APMAB-291LY)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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