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COMT Matched Antibody Pair (290) (APMAB-290LY)

This antibody pair set can be used for detecting and quantifying protein level of human COMT.
See all COMT antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-COMT polyclonal antibody, 100 ug
Detection Antibody
Anti-COMT Mouse monoclonal, IgG2b antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
COMT (Catechol-O-Methyltransferase) is a Protein Coding gene. Diseases associated with COMT include Schizophrenia and Panic Disorder 1. Among its related pathways are Cytochrome P450 - arranged by substrate type and Neurotransmitter Clearance In The Synaptic Cleft. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and catechol O-methyltransferase activity. An important paralog of this gene is LRTOMT.
Alternative Names
Catechol-O-Methyltransferase; EC 2.1.1.6; Epididymis Secretory Sperm Binding Protein Li 98n; Catechol-O-Methyltransferase Isoform; Testicular Tissue Protein Li 42; Catechol O-Methyltransferase; HEL-S-98n;
Entrez Gene ID
UniProt ID

Sprague, B. N., Rosso, A. L., Zhu, X., Bohnen, N. I., & Rosano, C. (2021). Catechol‐O‐methyltransferase (COMT) polymorphism predicts rapid gait speed changes in healthy older adults. Journal of the American Geriatrics Society, 69(11), 3194-3202.

Cao, C., Cao, L., & Chen, J. (2019). Differences in sensitivity to environment depending on Catechol-O-Methyltransferase (COMT) gene? A meta-analysis of child and adolescent gene-by-environment studies. Journal of Youth and Adolescence, 48(4), 655-667.

Nogueira, N. G., Fernandes, L. A., Ferreira, B. P., Batista, M. T., Alves, K. C., & Parma, J. O. (2019). Association between the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism and manual performance asymmetries. Perceptual and Motor Skills, 126(3), 349-365.

Nogueira, N. G. D. H. M., Bacelar, M. F. B., de Paula Ferreira, B., Parma, J. O., & Lage, G. M. (2019). Association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and motor behavior in healthy adults: a study review. Brain Research Bulletin, 144, 223-232.

Satterfield, B. C., Hinson, J. M., Whitney, P., Schmidt, M. A., Wisor, J. P., & Van Dongen, H. P. (2018). Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation. Cortex, 99, 179-186.

Patel, C. N., Georrge, J. J., Modi, K. M., Narechania, M. B., Patel, D. P., Gonzalez, F. J., & Pandya, H. A. (2018). Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics, 36(15), 3938-3957.

Parkin, G. M., Udawela, M., Gibbons, A., Scarr, E., & Dean, B. (2018). Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex. Journal of human genetics, 63(12), 1251-1258.

Lin, C. H., Chaudhuri, K., Fan, J. Y., Ko, C. I., Rizos, A., Chang, C. W., ... & Wu, Y. R. (2017). Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease. Scientific reports, 7(1), 1-10.

Bastos, P., Gomes, T., & Ribeiro, L. (2017). Catechol-O-methyltransferase (COMT): an update on its role in cancer, neurological and cardiovascular diseases. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173, 1-39.

Matsuzaka, C. T., Christofolini, D., Ota, V. K., Gadelha, A., Berberian, A. A., Noto, C., ... & Bressan, R. A. (2017). Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls. Brazilian Journal of Psychiatry, 39, 302-308.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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