DUT

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
Full Name
Deoxyuridine Triphosphatase
Research Area
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Biological Process
DNA replication Source: ProtInc
dUMP biosynthetic process Source: GO_Central
dUTP catabolic process Source: GO_Central
Nucleobase-containing compound metabolic process Source: ProtInc
Cellular Location
Isoform 2: Nucleus
Isoform 3: Mitochondrion
PTM
Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.
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Anti-DUT antibodies

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Mouse Anti-DUT Recombinant Antibody (CBYCD-451) (V2LY-0425-LY1101)

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Target: DUT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYCD-451
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DUT Recombinant Antibody (D1920) (V2LY-0425-LY1100)

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Target: DUT
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat, Dog, Cattle, Pig
Clone: D1920
Application*: WB, IP, IF, E, P
Datasheet SDS

DUT Matched Antibody Pair (355) (APMAB-355LY)

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Target: DUT
Specificity: Human
Datasheet SDS

Mouse Anti-DUT Recombinant Antibody (CBYCD-451) (CBMAB-D1921-YC)

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Target: DUT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCD-451
Application*: E, WB, P, IC, IF
Datasheet SDS

Mouse Anti-DUT Recombinant Antibody (1C9) (CBMAB-D1920-YC)

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Target: DUT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C9
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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