DUT Matched Antibody Pair (355) (APMAB-355LY)

Name: DUT Matched Antibody Pair (355)
SKU: APMAB-355LY
Rating: 5 (1 reviews)

See all DUT antibodies

Online Inquiry

Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-DUT monoclonal antibody, 100 ug

Detection Antibody

Anti-DUT Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

Alternative Names

Deoxyuridine Triphosphatase; DUTP Pyrophosphatase; DUTP Diphosphatase; EC 3.6.1.23; DUTPase; Deoxyuridine 5-Triphosphate Nucleotidohydrolase, Mitochondrial; DUTP Nucleotidohydrolase;

Entrez Gene ID

1854

UniProt ID

P33316

More Infomation

References

Weng, G. X., Ling, T., Hou, W., Li, S. N., Chen, T., Zhang, Z., ... & Xu, L. G. (2021). Mitochondrial DUT-M potentiates RLR-mediated antiviral signaling by enhancing VISA and TRAF2 association. Molecular Immunology, 132, 117-125.

Pérez-Moreno, G., Sánchez-Carrasco, P., Ruiz-Pérez, L. M., Johansson, N. G., Müller, S., Baragaña, B., ... & González-Pacanowska, D. (2019). Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity. Malaria journal, 18(1), 1-12.

Ye, F., Wang, H., Liu, J., Cheng, Q., Chen, X., & Chen, H. (2019). Genetic variants of the dUTPase-encoding gene DUT increase HR-HPV infection rate and cervical squamous cell carcinoma risk. Scientific reports, 9(1), 1-9.

Alam, M. S., Moriyama, H., & Matsumoto, M. (2018). Inhibition of Dr‐dut gene causes DNA damage in planarian. Molecular reproduction and development, 85(3), 188-196.

Ji, D., Kietrys, A. M., Lee, Y., & Kool, E. T. (2018). ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase. Bioconjugate chemistry, 29(5), 1614-1621.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used DUT Matched Antibody Pair (355)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-DUT Recombinant Antibody (CBYCD-451)

Mouse Anti-DUT Recombinant Antibody (D1920)

Mouse Anti-DUT Recombinant Antibody (CBYCD-451)

Mouse Anti-DUT Recombinant Antibody (1C9)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: