EPN1

EPN1 is a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types.

Epsin 1

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity).

Regulates receptor-mediated endocytosis (PubMed:10557078, PubMed:10393179).

Embryonic organ development Source: Ensembl
Endocytosis Source: GO_Central
Female pregnancy Source: Ensembl
In utero embryonic development Source: Ensembl
Negative regulation of sprouting angiogenesis Source: BHF-UCL
Notch signaling pathway Source: Ensembl

Cell membrane; Nucleus; Cytoplasm; Clathrin-coated pit. Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).

Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.
Ubiquitinated.