Sign in or Register   Sign in or Register
  |  

Recombinant Mouse Anti-EPN1 Recombinant Antibody (ZZ3-1) (CBMAB-XB0401-YC)

Provided herein is a Mouse Recombinant Antibody against Epsin 1. The antibody can be used for immunoassay techniques, such as IF, IP, WB.
See all EPN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
ZZ3-1
Application
IF, IP, WB

Basic Information

Specificity
Human, Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Epsin 1
Introduction
EPN1 is a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types.
Entrez Gene ID
Human29924
Mouse13854
UniProt ID
HumanQ9Y6I3
MouseQ80VP1
Alternative Names
Epsin 1; EH Domain-Binding Mitotic Phosphoprotein; EPS-15-Interacting Protein 1; Epsin-1;
Research Area
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity).

Regulates receptor-mediated endocytosis (PubMed:10557078, PubMed:10393179).
Biological Process
Embryonic organ development Source: Ensembl
Endocytosis Source: GO_Central
Female pregnancy Source: Ensembl
In utero embryonic development Source: Ensembl
Negative regulation of sprouting angiogenesis Source: BHF-UCL
Notch signaling pathway Source: Ensembl
Cellular Location
Cell membrane; Nucleus; Cytoplasm; Clathrin-coated pit. Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).
PTM
Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.
Ubiquitinated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Recombinant Mouse Anti-EPN1 Recombinant Antibody (ZZ3-1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare