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Mouse Anti-EPN1 (AA 106-254) Recombinant Antibody (6F7F9) (CBMAB-E0232-FY)

This product is mouse antibody that recognizes EPN1. The antibody 6F7F9 can be used for immunoassay techniques such as: ELISA, WB, IHC-P, IF, FC.
See all EPN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6F7F9
Application
ELISA, WB, IHC-P, IF, FC

Basic Information

Immunogen
Purified recombinant fragment of human EPN1 expressed in E.coli
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 106-254

Target

Full Name
Epsin 1
Introduction
This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types.
Entrez Gene ID
29924
UniProt ID
Q9Y6I3
Alternative Names
Epsin 1; EH Domain-Binding Mitotic Phosphoprotein; EPS-15-Interacting Protein 1; Epsin-1
Research Area
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity).

Regulates receptor-mediated endocytosis (PubMed:10557078, PubMed:10393179).
Biological Process
Embryonic organ development Source: Ensembl
Endocytosis Source: GO_Central
Female pregnancy Source: Ensembl
In utero embryonic development Source: Ensembl
Negative regulation of sprouting angiogenesis Source: BHF-UCL
Notch signaling pathway Source: Ensembl
Cellular Location
Cell membrane; Nucleus; Cytoplasm; Clathrin-coated pit. Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).
PTM
Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.
Ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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