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Mouse Anti-EPN1 Recombinant Antibody (CBT3298) (V2LY-0625-LY173)


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Tested Data
Mouse Anti-EPN1 Recombinant Antibody (CBT3298) (V2LY-0625-LY173) in WB
Mouse Anti-EPN1 Recombinant Antibody (CBT3298) (V2LY-0625-LY173) in WB
Mouse Anti-EPN1 Recombinant Antibody (CBT3298) (V2LY-0625-LY173) in WB
Mouse Anti-EPN1 Recombinant Antibody (CBT3298) (V2LY-0625-LY173) in WB
Mouse Anti-EPN1 Recombinant Antibody (CBT3298) (V2LY-0625-LY173) in FC
Mouse Anti-EPN1 Recombinant Antibody (CBT3298) (V2LY-0625-LY173) in FC
Mouse Anti-EPN1 Recombinant Antibody (CBT3298) (V2LY-0625-LY173) in ELISA
Mouse Anti-EPN1 Recombinant Antibody (CBT3298) (V2LY-0625-LY173) in ELISA

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3298
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human EPN1 (AA: 106-254) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
29924
UniProt ID
Q9Y6I3
Research Area
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity).

Regulates receptor-mediated endocytosis (PubMed:10557078, PubMed:10393179).
Biological Process
Embryonic organ development Source: Ensembl
Endocytosis Source: GO_Central
Female pregnancy Source: Ensembl
In utero embryonic development Source: Ensembl
Negative regulation of sprouting angiogenesis Source: BHF-UCL
Notch signaling pathway Source: Ensembl
Cellular Location
Cell membrane; Nucleus; Cytoplasm; Clathrin-coated pit. Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).
PTM
Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.
Ubiquitinated.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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