F11R

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Full Name

F11 Receptor

Research Area

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913).

The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity).

Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity).

Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992).

Involved in platelet activation (PubMed:10753840).

(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.

(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.

Biological Process

Actomyosin structure organization Source: UniProtKB
Cell-cell adhesion Source: ARUK-UCL
Cellular response to mechanical stimulus Source: ARUK-UCL
Establishment of endothelial intestinal barrier Source: UniProtKB
Inflammatory response Source: ProtInc
Intestinal absorption Source: UniProtKB
Leukocyte cell-cell adhesion Source: ARUK-UCL
Maintenance of blood-brain barrier Source: ARUK-UCL
Memory T cell extravasation Source: ARUK-UCL
Negative regulation of GTPase activity Source: UniProtKB
Negative regulation of stress fiber assembly Source: ARUK-UCL
Positive regulation of blood pressure Source: Ensembl
Positive regulation of establishment of endothelial barrier Source: ARUK-UCL
Positive regulation of GTPase activity Source: UniProtKB
Positive regulation of platelet aggregation Source: ARUK-UCL
Positive regulation of Rho protein signal transduction Source: ARUK-UCL
Protein localization to bicellular tight junction Source: ARUK-UCL
Protein localization to plasma membrane Source: UniProtKB
Regulation of actin cytoskeleton organization Source: ARUK-UCL
Regulation of actin cytoskeleton reorganization Source: UniProtKB
Regulation of bicellular tight junction assembly Source: ARUK-UCL
Regulation of cell shape Source: ARUK-UCL
Regulation of cytokine production Source: Ensembl
Regulation of cytoskeleton organization Source: ARUK-UCL
Regulation of membrane permeability Source: UniProtKB
Response to radiation Source: Ensembl

Cellular Location

Cell membrane; Tight junction. Localized at tight junctions of both epithelial and endothelial cells.

Topology

Extracellular: 28-238
Helical: 239-259
Cytoplasmic: 260-299

PTM

N-glycosylated.

F11R

Anti-F11R antibodies