Rat Anti-F11R Recombinant Antibody (CBLXF-003) (CBMAB-2153CQ)

Name: Rat Anti-F11R Recombinant Antibody (CBLXF-003)
SKU: CBMAB-2153CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBLXF-003

Application

FC, IHC, IP

Immunogen

MTE1/MTE2 stromal cell lines.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
FC	1:100-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

F11 Receptor

Introduction

F11R (F11 Receptor) is a Protein Coding gene. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. Diseases associated with F11R include Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma. An important paralog of this gene is JAM2.

Entrez Gene ID

16456

UniProt ID

O88792

Alternative Names

JAM; Jcam; JAM-1; JAM-A; Jcam1; Ly106; ESTM33; AA638916; 9130004G24

Research Area

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913).

The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity).

Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity).

Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992).

Involved in platelet activation (PubMed:10753840).

(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.

(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.

Biological Process

Actomyosin structure organization Source: UniProtKB
Cell-cell adhesion Source: ARUK-UCL
Cellular response to mechanical stimulus Source: ARUK-UCL
Establishment of endothelial intestinal barrier Source: UniProtKB
Inflammatory response Source: ProtInc
Intestinal absorption Source: UniProtKB
Leukocyte cell-cell adhesion Source: ARUK-UCL
Maintenance of blood-brain barrier Source: ARUK-UCL
Memory T cell extravasation Source: ARUK-UCL
Negative regulation of GTPase activity Source: UniProtKB
Negative regulation of stress fiber assembly Source: ARUK-UCL
Positive regulation of blood pressure Source: Ensembl
Positive regulation of establishment of endothelial barrier Source: ARUK-UCL
Positive regulation of GTPase activity Source: UniProtKB
Positive regulation of platelet aggregation Source: ARUK-UCL
Positive regulation of Rho protein signal transduction Source: ARUK-UCL
Protein localization to bicellular tight junction Source: ARUK-UCL
Protein localization to plasma membrane Source: UniProtKB
Regulation of actin cytoskeleton organization Source: ARUK-UCL
Regulation of actin cytoskeleton reorganization Source: UniProtKB
Regulation of bicellular tight junction assembly Source: ARUK-UCL
Regulation of cell shape Source: ARUK-UCL
Regulation of cytokine production Source: Ensembl
Regulation of cytoskeleton organization Source: ARUK-UCL
Regulation of membrane permeability Source: UniProtKB
Response to radiation Source: Ensembl

Cellular Location

Cell membrane; Tight junction. Localized at tight junctions of both epithelial and endothelial cells.

Topology

Extracellular: 28-238
Helical: 239-259
Cytoplasmic: 260-299

PTM

N-glycosylated.

Czubak-Prowizor, K., Babinska, A., & Swiatkowska, M. (2022). The F11 receptor (F11R)/junctional adhesion molecule-A (JAM-A)(F11R/JAM-A) in cancer progression. Molecular and Cellular Biochemistry, 477(1), 79-98.

Li, Y., Peng, L., Cao, X., Yang, K., Wang, Z., Xiao, Y., ... & Liu, H. (2022). The Long Non-Coding RNA HOXC-AS3 Promotes Glioma Progression by Sponging miR-216 to Regulate F11R Expression. Frontiers in oncology, 12, 845009-845009.

Adedayo, A., Eluwole, A., Tedla, F., Kremer, A., Khan, M., Mastrogiovanni, N., ... & Bakillah, A. (2022). Relationship between the Soluble F11 Receptor and Annexin A5 in African Americans Patients with Type-2 Diabetes Mellitus. Biomedicines, 10(8), 1818.

Guo, X., Gu, Y., Guo, C., Pei, L., & Hao, C. (2022). LINC01146/F11R facilitates growth and metastasis of prostate cancer under the regulation of TGF-β. The Journal of Steroid Biochemistry and Molecular Biology, 106193.

Tian, Y., Fopiano, K. A., Buncha, V., Lang, L., Rudic, R. D., Filosa, J. A., ... & Bagi, Z. (2022). Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17. GeroScience, 44(1), 349-369.

Bednarek, R., Selmi, A., Wojkowska, D., Karolczak, K., Popielarski, M., Stasiak, M., ... & Swiatkowska, M. (2020). Functional inhibition of F11 receptor (F11R/junctional adhesion molecule-A/JAM-A) activity by a F11R-derived peptide in breast cancer and its microenvironment. Breast Cancer Research and Treatment, 179(2), 325-335.

Babinska, A., Clement, C. C., Li, Y., Wzorek, J., Przygodzki, T., Talar, M., ... & Salifu, M. O. (2020). In vivo data: treatment with the F11R/JAM-A peptide 4D decreases mortality and reduces the generation of atherosclerotic plaques in ApoE-deficient mice. Data in brief, 30, 105516.

Babinska, A., Clement, C. C., Przygodzki, T., Talar, M., Li, Y., Braun, M., ... & Salifu, M. O. (2019). A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis. Atherosclerosis, 284, 92-101.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

F11R Matched Antibody Pair (393) (CAT#: APMAB-393LY)

F11R Matched Antibody Pair (394) (CAT#: APMAB-394LY)

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F11R Matched Antibody Pair (394) (CAT#: APMAB-394LY)

Mouse Anti-F11R Recombinant Antibody (402) (CAT#: CBMAB-0026-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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