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Human Anti-F11R Recombinant Antibody (CBXC-0892) (CBMAB-C2007-CQ)

This product is a recombinant human antibody that recognizes F11R. The antibody CBXC-0892 can be used for immunoassay techniques such as: FC.
See all F11R antibodies

Summary

Host Animal
Human
Specificity
Human
Clone
CBXC-0892
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F11 Receptor
Introduction
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Entrez Gene ID
UniProt ID
Alternative Names
F11 Receptor; Junctional Adhesion Molecule 1; Platelet Adhesion Molecule 1; Platelet F11 Receptor; PAM-1; JAM1; JCAM; Junctional Adhesion Molecule A;
Research Area
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913).

The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity).

Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity).

Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992).

Involved in platelet activation (PubMed:10753840).

(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.

(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Biological Process
Actomyosin structure organization Source: UniProtKB
Cell-cell adhesion Source: ARUK-UCL
Cellular response to mechanical stimulus Source: ARUK-UCL
Establishment of endothelial intestinal barrier Source: UniProtKB
Inflammatory response Source: ProtInc
Intestinal absorption Source: UniProtKB
Leukocyte cell-cell adhesion Source: ARUK-UCL
Maintenance of blood-brain barrier Source: ARUK-UCL
Memory T cell extravasation Source: ARUK-UCL
Negative regulation of GTPase activity Source: UniProtKB
Negative regulation of stress fiber assembly Source: ARUK-UCL
Positive regulation of blood pressure Source: Ensembl
Positive regulation of establishment of endothelial barrier Source: ARUK-UCL
Positive regulation of GTPase activity Source: UniProtKB
Positive regulation of platelet aggregation Source: ARUK-UCL
Positive regulation of Rho protein signal transduction Source: ARUK-UCL
Protein localization to bicellular tight junction Source: ARUK-UCL
Protein localization to plasma membrane Source: UniProtKB
Regulation of actin cytoskeleton organization Source: ARUK-UCL
Regulation of actin cytoskeleton reorganization Source: UniProtKB
Regulation of bicellular tight junction assembly Source: ARUK-UCL
Regulation of cell shape Source: ARUK-UCL
Regulation of cytokine production Source: Ensembl
Regulation of cytoskeleton organization Source: ARUK-UCL
Regulation of membrane permeability Source: UniProtKB
Response to radiation Source: Ensembl
Cellular Location
Cell membrane; Tight junction. Localized at tight junctions of both epithelial and endothelial cells.
Topology
Extracellular: 28-238
Helical: 239-259
Cytoplasmic: 260-299
PTM
N-glycosylated.

Czubak-Prowizor, K., Babinska, A., & Swiatkowska, M. (2022). The F11 receptor (F11R)/junctional adhesion molecule-A (JAM-A)(F11R/JAM-A) in cancer progression. Molecular and Cellular Biochemistry, 477(1), 79-98.

Li, Y., Peng, L., Cao, X., Yang, K., Wang, Z., Xiao, Y., ... & Liu, H. (2022). The Long Non-Coding RNA HOXC-AS3 Promotes Glioma Progression by Sponging miR-216 to Regulate F11R Expression. Frontiers in oncology, 12, 845009-845009.

Adedayo, A., Eluwole, A., Tedla, F., Kremer, A., Khan, M., Mastrogiovanni, N., ... & Bakillah, A. (2022). Relationship between the Soluble F11 Receptor and Annexin A5 in African Americans Patients with Type-2 Diabetes Mellitus. Biomedicines, 10(8), 1818.

Guo, X., Gu, Y., Guo, C., Pei, L., & Hao, C. (2022). LINC01146/F11R facilitates growth and metastasis of prostate cancer under the regulation of TGF-β. The Journal of Steroid Biochemistry and Molecular Biology, 106193.

Tian, Y., Fopiano, K. A., Buncha, V., Lang, L., Rudic, R. D., Filosa, J. A., ... & Bagi, Z. (2022). Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17. GeroScience, 44(1), 349-369.

Bednarek, R., Selmi, A., Wojkowska, D., Karolczak, K., Popielarski, M., Stasiak, M., ... & Swiatkowska, M. (2020). Functional inhibition of F11 receptor (F11R/junctional adhesion molecule-A/JAM-A) activity by a F11R-derived peptide in breast cancer and its microenvironment. Breast Cancer Research and Treatment, 179(2), 325-335.

Babinska, A., Clement, C. C., Li, Y., Wzorek, J., Przygodzki, T., Talar, M., ... & Salifu, M. O. (2020). In vivo data: treatment with the F11R/JAM-A peptide 4D decreases mortality and reduces the generation of atherosclerotic plaques in ApoE-deficient mice. Data in brief, 30, 105516.

Babinska, A., Clement, C. C., Przygodzki, T., Talar, M., Li, Y., Braun, M., ... & Salifu, M. O. (2019). A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis. Atherosclerosis, 284, 92-101.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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