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MVP

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Full Name

Major Vault Protein

Function

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Biological Process

ERBB signaling pathway Source: UniProtKB
mRNA transport Source: UniProtKB-KW
Negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of protein autophosphorylation Source: UniProtKB
Negative regulation of protein tyrosine kinase activity Source: UniProtKB
Protein transport Source: UniProtKB-KW

Cellular Location

Nucleus
nuclear pore complex
Cytoplasm
Other locations
perinuclear region
Note: 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).

PTM

Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11.

Anti-MVP antibodies

Mouse Anti-MVP Recombinant Antibody (CBFYM-2846) (CBMAB-M3039-FY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBFYM-2846

Application*: IH, P, IP, WB

Mouse Anti-MVP (AA 12-39) Recombinant Antibody (CBFYM-2844) (CBMAB-M3037-FY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2844

Application*: WB, E

Mouse Anti-MVP (AA 1-893) Recombinant Antibody (CBFYM-2843) (CBMAB-M3036-FY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-2843

Application*: E, IF, P, WB

Mouse Anti-MVP Recombinant Antibody (CBFYM-2842) (CBMAB-M3035-FY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-2842

Application*: IF, IH, F, WB

Mouse Anti-MVP (AA 1-894) Recombinant Antibody (CBFYM-0499) (CBMAB-M0627-FY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-0499

Application*: E, IC, IH, WB

Rabbit Anti-MVP Recombinant Antibody (CBFYM-0303) (CBMAB-M0368-FY)

SDS

Target: MVP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-0303

Application*: WB, P, F, IF

Mouse Anti-MVP Recombinant Antibody (CBFYM-0223) (CBMAB-M0267-FY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0223

Application*: F, IF, IH, WB

Mouse Anti-MVP Recombinant Antibody (CBFYM-0017) (CBMAB-M0021-FY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat, Human

Clone: CBFYM-0017

Application*: WB, IP, P, F

Mouse Anti-MVP Recombinant Antibody (MVP-37) (CBMAB-L0385-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: MVP-37

Application*: IH, WB

Mouse Anti-MVP Recombinant Antibody (LRP-56) (CBMAB-L0384-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: LRP-56

Application*: F, IC, IH

Rat Anti-MVP Recombinant Antibody (LMR5) (CBMAB-L0383-YJ)

SDS

Target: MVP

Host: Rat

Antibody Isotype: IgG

Specificity: Human

Clone: LMR5

Application*: F, IH

Mouse Anti-MVP Recombinant Antibody (CBYJL-268) (CBMAB-L0382-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-268

Application*: P, C, F

Mouse Anti-MVP Recombinant Antibody (6D535) (CBMAB-L0379-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 6D535

Application*: IH, WB

Mouse Anti-MVP Recombinant Antibody (5F242) (CBMAB-L0378-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5F242

Application*: IH, F

Mouse Anti-MVP Recombinant Antibody (CBYJL-266) (CBMAB-L0377-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-266

Application*: E, IF, IH, WB

Mouse Anti-MVP Recombinant Antibody (11D115) (CBMAB-L0376-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 11D115

Application*: E

Mouse Anti-MVP Recombinant Antibody (1032) (CBMAB-L0375-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Rat

Clone: 1032

Application*: WB, IH

Mouse Anti-MVP Recombinant Antibody (1027) (CBMAB-L0374-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: 1027

Application*: WB, IH

Mouse Anti-MVP Recombinant Antibody (1014) (CBMAB-L0373-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1014

Application*: WB, IP, IF, P

Mouse Anti-MVP Recombinant Antibody (1011) (CBMAB-L0372-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1011

Application*: WB, IH

Mouse Anti-MVP Recombinant Antibody (0.N.389) (CBMAB-L0371-YJ)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Rat

Clone: 0.N.389

Application*: WB, IP, IH, F

Mouse Anti-MVP Recombinant Antibody (A1262) (CBMAB-AP4361LY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1262

Application*: FC, IF, IHC

Mouse Anti-MVP Recombinant Antibody (A1261) (CBMAB-AP4358LY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1261

Application*: FC, IF, IHC

Mouse Anti-MVP Recombinant Antibody (A1260) (CBMAB-AP4363LY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1260

Application*: FC, IF

Mouse Anti-MVP Recombinant Antibody (8B12) (CBMAB-BR362LY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 8B12

Application*: FC, IHC-P, WB

Mouse Anti-MVP Recombinant Antibody (2H3-1A6) (CBMAB-A5700-LY)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2H3-1A6

Application*: WB, E

Mouse Anti-MVP Recombinant Antibody (CBYCL-616) (CBMAB-L0517-YC)

SDS

Target: MVP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCL-616

Application*: WB, IC, P, C, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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