MVP

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Full Name
Major Vault Protein
Function
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Biological Process
ERBB signaling pathway Source: UniProtKB
mRNA transport Source: UniProtKB-KW
Negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of protein autophosphorylation Source: UniProtKB
Negative regulation of protein tyrosine kinase activity Source: UniProtKB
Protein transport Source: UniProtKB-KW
Cellular Location
Nucleus
nuclear pore complex
Cytoplasm
Other locations
perinuclear region
Note: 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
PTM
Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11.
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Anti-MVP antibodies

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Mouse Anti-MVP (AA 1-893) Recombinant Antibody (CBFYM-2843) (CBMAB-M3036-FY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2843
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (A1262) (CBMAB-AP4361LY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1262
Application*: FC, IF, IHC
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (A1261) (CBMAB-AP4358LY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1261
Application*: FC, IF, IHC
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (A1260) (CBMAB-AP4363LY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1260
Application*: FC, IF
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (8B12) (CBMAB-BR362LY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 8B12
Application*: FC, IHC-P, WB
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (2H3-1A6) (CBMAB-A5700-LY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H3-1A6
Application*: WB, E
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (CBFYM-2846) (CBMAB-M3039-FY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBFYM-2846
Application*: IH, P, IP, WB
Datasheet SDS

Mouse Anti-MVP (AA 12-39) Recombinant Antibody (CBFYM-2844) (CBMAB-M3037-FY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2844
Application*: WB, E
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (CBFYM-2842) (CBMAB-M3035-FY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2842
Application*: IF, IH, F, WB
Datasheet SDS

Mouse Anti-MVP (AA 1-894) Recombinant Antibody (CBFYM-0499) (CBMAB-M0627-FY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0499
Application*: E, IC, IH, WB
Datasheet SDS

Rabbit Anti-MVP Recombinant Antibody (CBFYM-0303) (CBMAB-M0368-FY)

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Target: MVP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0303
Application*: WB, P, F, IF
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (CBFYM-0223) (CBMAB-M0267-FY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0223
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (CBFYM-0017) (CBMAB-M0021-FY)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human
Clone: CBFYM-0017
Application*: WB, IP, P, F
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (CBYCL-616) (CBMAB-L0517-YC)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-616
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (MVP-37) (CBMAB-L0385-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: MVP-37
Application*: IH, WB
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (LRP-56) (CBMAB-L0384-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: LRP-56
Application*: F, IC, IH
Datasheet SDS

Rat Anti-MVP Recombinant Antibody (LMR5) (CBMAB-L0383-YJ)

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Target: MVP
Host: Rat
Antibody Isotype: IgG
Specificity: Human
Clone: LMR5
Application*: F, IH
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (CBYJL-268) (CBMAB-L0382-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-268
Application*: P, C, F
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (6D535) (CBMAB-L0379-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6D535
Application*: IH, WB
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (5F242) (CBMAB-L0378-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5F242
Application*: IH, F
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (CBYJL-266) (CBMAB-L0377-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-266
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (11D115) (CBMAB-L0376-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11D115
Application*: E
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (1032) (CBMAB-L0375-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Rat
Clone: 1032
Application*: WB, IH
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (1027) (CBMAB-L0374-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 1027
Application*: WB, IH
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (1014) (CBMAB-L0373-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1014
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (1011) (CBMAB-L0372-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1011
Application*: WB, IH
Datasheet SDS

Mouse Anti-MVP Recombinant Antibody (0.N.389) (CBMAB-L0371-YJ)

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Target: MVP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 0.N.389
Application*: WB, IP, IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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