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Mouse Anti-MVP Recombinant Antibody (5F242) (CBMAB-L0378-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Major Vault Protein (MVP). The antibody can be used for immunoassay techniques, such as IHC, FC.
Host Animal
Mouse
Application
IHC, FC
Immunogen
Reacts with an internal epitope of LRP/Major Vault Protein (P110), which is strongly overexpressed in various human non-P-glycoprotein multidrug-resistance (MDR) tumor cell lines. Not applicable in immunoblot. Species Crossreactivity: Human.
Antibody Isotype
IgG2b
Specificity
Human
Cross Reactivity
Human
Clone
5F242
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
Gene of MVP encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may paticipate in nucleo-cytoplasmic transport. MVP may play a role in multiple cellular processes by regulating the JAK/STAT, MAP kinase and phosphoinositide 3-kinase/Akt signaling pathways. MVP also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been found for this gene.
Alternative Name
Major Vault Protein; Lung Resistance-Related Protein; LRP; Testicular Secretory Protein Li 30; VAULT1
Entrez Gene ID
UniProt ID