Reacts with an internal epitope of LRP/Major Vault Protein (P110), which is strongly overexpressed in various human non-P-glycoprotein multidrug-resistance (MDR) tumor cell lines. Not applicable in immunoblot. Species Crossreactivity: Human.
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Gene of MVP encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may paticipate in nucleo-cytoplasmic transport. MVP may play a role in multiple cellular processes by regulating the JAK/STAT, MAP kinase and phosphoinositide 3-kinase/Akt signaling pathways. MVP also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been found for this gene.
Major Vault Protein; Lung Resistance-Related Protein; LRP; Testicular Secretory Protein Li 30; VAULT1