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Mouse Anti-MVP Recombinant Antibody (2H3-1A6) (CBMAB-A5700-LY)

The product is antibody recognizes MVP. The antibody 2H3-1A6 immunoassay techniques such as: WB, ELISA.
See all MVP antibodies
Published Data
Fig.1 Western blot analysis of nontumorous tissue and HCC tumor tissue, respectively.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2H3-1A6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MVP (AAH15623, 1 a.a. ~ 893 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Major Vault Protein
Introduction
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [provided by RefSeq]
Entrez Gene ID
9961
UniProt ID
Q14764
Alternative Names
LRP; VAULT1
Function
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Biological Process
ERBB signaling pathway Source: UniProtKB
mRNA transport Source: UniProtKB-KW
Negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of protein autophosphorylation Source: UniProtKB
Negative regulation of protein tyrosine kinase activity Source: UniProtKB
Protein transport Source: UniProtKB-KW
Cellular Location
Nucleus
nuclear pore complex
Cytoplasm
Other locations
perinuclear region
Note: 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
PTM
Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11.

Wang, R., Yang, Y., Zhang, Z., Zhao, N., Wiemer, E. A., Ben, J., ... & Yuan, L. (2023). Major vault protein (MVP) suppresses aging-and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts. Cell Death & Disease, 14(9), 604.

Liu, Q., Pan, J., Bao, L., Xu, C., Qi, Y., Jiang, B., ... & Chen, Q. (2022). Major vault protein prevents atherosclerotic plaque destabilization by suppressing macrophage ASK1-JNK signaling. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(5), 580-596.

Yuan, L., Zhao, N., Wang, J., Liu, Y., Meng, L., Guo, S., ... & Ma, J. (2021). Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition. Theranostics, 11(15), 7247.

Ramberg, H., Richardsen, E., de Souza, G. A., Rakaee, M., Stensland, M. E., Braadland, P. R., ... & Andersen, S. (2021). Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer. Carcinogenesis, 42(5), 685-693.

Wang, W., Xiong, L., Wang, P., Wang, F., & Ma, Q. (2020). Major vault protein plays important roles in viral infection. IUBMB life, 72(4), 624-631.

Grossi, S., Fenini, G., Kockmann, T., Hennig, P., Di Filippo, M., & Beer, H. D. (2020). Inactivation of the cytoprotective major vault protein by caspase-1 and-9 in epithelial cells during apoptosis. Journal of Investigative Dermatology, 140(7), 1335-1345.

Yu, H., Li, M., He, R., Fang, P., Wang, Q., Yi, Y., ... & Liu, S. (2020). Major vault protein promotes hepatocellular carcinoma through targeting interferon regulatory factor 2 and decreasing p53 activity. Hepatology, 72(2), 518-534.

Ben, J., Jiang, B., Wang, D., Liu, Q., Zhang, Y., Qi, Y., ... & Chen, Q. (2019). Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation. Nature communications, 10(1), 1801.

Lehuédé, C., Li, X., Dauvillier, S., Vaysse, C., Franchet, C., Clement, E., ... & Muller, C. (2019). Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP). Breast Cancer Research, 21, 1-17.

Bai, H., Wang, C., Qi, Y., Xu, J., Li, N., Chen, L., ... & Chen, Q. (2019). Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway. BMC cancer, 19(1), 1-13.

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For research use only. Not intended for any clinical use.

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