Human MVP ELISA Kit (V2LY-0626-LY1845)

Name: Human MVP ELISA Kit
SKU: V2LY-0626-LY1845
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.018 ng/mL

Detection Range

0.05-15 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

99.3 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Major Vault Protein

Function

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Biological Process

ERBB signaling pathway Source: UniProtKB
mRNA transport Source: UniProtKB-KW
Negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of protein autophosphorylation Source: UniProtKB
Negative regulation of protein tyrosine kinase activity Source: UniProtKB
Protein transport Source: UniProtKB-KW

Cellular Location

Nucleus
nuclear pore complex
Cytoplasm
Other locations
perinuclear region
Note: 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).

PTM

Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11.

Wang, R., Yang, Y., Zhang, Z., Zhao, N., Wiemer, E. A., Ben, J., ... & Yuan, L. (2023). Major vault protein (MVP) suppresses aging-and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts. Cell Death & Disease, 14(9), 604.

Liu, Q., Pan, J., Bao, L., Xu, C., Qi, Y., Jiang, B., ... & Chen, Q. (2022). Major vault protein prevents atherosclerotic plaque destabilization by suppressing macrophage ASK1-JNK signaling. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(5), 580-596.

Yuan, L., Zhao, N., Wang, J., Liu, Y., Meng, L., Guo, S., ... & Ma, J. (2021). Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition. Theranostics, 11(15), 7247.

Ramberg, H., Richardsen, E., de Souza, G. A., Rakaee, M., Stensland, M. E., Braadland, P. R., ... & Andersen, S. (2021). Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer. Carcinogenesis, 42(5), 685-693.

Wang, W., Xiong, L., Wang, P., Wang, F., & Ma, Q. (2020). Major vault protein plays important roles in viral infection. IUBMB life, 72(4), 624-631.

Grossi, S., Fenini, G., Kockmann, T., Hennig, P., Di Filippo, M., & Beer, H. D. (2020). Inactivation of the cytoprotective major vault protein by caspase-1 and-9 in epithelial cells during apoptosis. Journal of Investigative Dermatology, 140(7), 1335-1345.

Yu, H., Li, M., He, R., Fang, P., Wang, Q., Yi, Y., ... & Liu, S. (2020). Major vault protein promotes hepatocellular carcinoma through targeting interferon regulatory factor 2 and decreasing p53 activity. Hepatology, 72(2), 518-534.

Ben, J., Jiang, B., Wang, D., Liu, Q., Zhang, Y., Qi, Y., ... & Chen, Q. (2019). Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation. Nature communications, 10(1), 1801.

Lehuédé, C., Li, X., Dauvillier, S., Vaysse, C., Franchet, C., Clement, E., ... & Muller, C. (2019). Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP). Breast Cancer Research, 21, 1-17.

Bai, H., Wang, C., Qi, Y., Xu, J., Li, N., Chen, L., ... & Chen, Q. (2019). Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway. BMC cancer, 19(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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