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Mouse Anti-MVP Recombinant Antibody (CBFYM-2846) (CBMAB-M3039-FY)

This product is mouse antibody that recognizes MVP. The antibody CBFYM-2846 can be used for immunoassay techniques such as: IHC, IHC-P, IP, WB.
See all MVP antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBFYM-2846
Antibody Isotype
IgG1
Application
IHC, IHC-P, IP, WB

Basic Information

Immunogen
Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Major Vault Protein
Introduction
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Entrez Gene ID
Human9961
Rat64681
UniProt ID
HumanQ14764
RatQ62667
Alternative Names
Major Vault Protein; Lung Resistance-Related Protein; LRP; Testicular Secretory Protein Li 30; VAULT1
Function
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Biological Process
ERBB signaling pathway Source: UniProtKB
mRNA transport Source: UniProtKB-KW
Negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Negative regulation of protein autophosphorylation Source: UniProtKB
Negative regulation of protein tyrosine kinase activity Source: UniProtKB
Protein transport Source: UniProtKB-KW
Cellular Location
Nucleus
nuclear pore complex
Cytoplasm
Other locations
perinuclear region
Note: 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
PTM
Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11.

Wang, R., Yang, Y., Zhang, Z., Zhao, N., Wiemer, E. A., Ben, J., ... & Yuan, L. (2023). Major vault protein (MVP) suppresses aging-and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts. Cell Death & Disease, 14(9), 604.

Liu, Q., Pan, J., Bao, L., Xu, C., Qi, Y., Jiang, B., ... & Chen, Q. (2022). Major vault protein prevents atherosclerotic plaque destabilization by suppressing macrophage ASK1-JNK signaling. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(5), 580-596.

Yuan, L., Zhao, N., Wang, J., Liu, Y., Meng, L., Guo, S., ... & Ma, J. (2021). Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition. Theranostics, 11(15), 7247.

Ramberg, H., Richardsen, E., de Souza, G. A., Rakaee, M., Stensland, M. E., Braadland, P. R., ... & Andersen, S. (2021). Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer. Carcinogenesis, 42(5), 685-693.

Wang, W., Xiong, L., Wang, P., Wang, F., & Ma, Q. (2020). Major vault protein plays important roles in viral infection. IUBMB life, 72(4), 624-631.

Grossi, S., Fenini, G., Kockmann, T., Hennig, P., Di Filippo, M., & Beer, H. D. (2020). Inactivation of the cytoprotective major vault protein by caspase-1 and-9 in epithelial cells during apoptosis. Journal of Investigative Dermatology, 140(7), 1335-1345.

Yu, H., Li, M., He, R., Fang, P., Wang, Q., Yi, Y., ... & Liu, S. (2020). Major vault protein promotes hepatocellular carcinoma through targeting interferon regulatory factor 2 and decreasing p53 activity. Hepatology, 72(2), 518-534.

Ben, J., Jiang, B., Wang, D., Liu, Q., Zhang, Y., Qi, Y., ... & Chen, Q. (2019). Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation. Nature communications, 10(1), 1801.

Lehuédé, C., Li, X., Dauvillier, S., Vaysse, C., Franchet, C., Clement, E., ... & Muller, C. (2019). Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP). Breast Cancer Research, 21, 1-17.

Bai, H., Wang, C., Qi, Y., Xu, J., Li, N., Chen, L., ... & Chen, Q. (2019). Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway. BMC cancer, 19(1), 1-13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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