PCK2

This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
Full Name
Phosphoenolpyruvate Carboxykinase 2, Mitochondrial
Function
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Biological Process
Cellular response to dexamethasone stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to glucose stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to insulin stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to tumor necrosis factorIEA:Ensembl
GluconeogenesisManual Assertion Based On ExperimentIBA:GO_Central
Glycerol biosynthetic process from pyruvateManual Assertion Based On ExperimentIBA:GO_Central
Hepatocyte differentiationManual Assertion Based On ExperimentIBA:GO_Central
NADH oxidationIEA:Ensembl
Oxaloacetate metabolic processIEA:Ensembl
Positive regulation of insulin secretionIEA:Ensembl
Propionate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Response to lipidManual Assertion Based On ExperimentIBA:GO_Central
Response to lipopolysaccharideIEA:Ensembl
Response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrial phosphoenolpyruvate carboxykinase deficiency (M-PEPCKD):
Metabolic disorder resulting from impaired gluconeogenesis. It is a rare disease with less than 10 cases reported in the literature. Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia. Autopsy reveals fatty infiltration of both the liver and kidneys. The disorder is transmitted as an autosomal recessive trait.
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Anti-PCK2 antibodies

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Mouse Anti-PCK2 Recombinant Antibody (CBYC-P219) (CBMAB-P1055-YC)

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Target: PCK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P219
Application*: WB, IC, P, C, E
Datasheet SDS

Rabbit Anti-PCK2 Recombinant Antibody (D3E11) (CBMAB-P1053-YC)

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Target: PCK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D3E11
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-PCK2 Recombinant Antibody (2C9) (CBMAB-P1052-YC)

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Target: PCK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C9
Application*: E, WB
Datasheet SDS

Human Recombinant PCK2 protein, GST Tag (V2LY-0526-LY5987)

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Target: PCK2
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 33-640
Tag: GST Tag
Datasheet SDS

Mouse Anti-PCK2 Recombinant Antibody (CBT1018) (V2LY-0625-LY3104)

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Target: PCK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: CBT1018
Application*: WB
Datasheet SDS

Mouse Anti-PCK2 Recombinant Antibody (CBT2074) (V2LY-0625-LY1240)

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Target: PCK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2074
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-PCK2 Recombinant Antibody (CBT3818) (V2LY-0625-LY1191)

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Target: PCK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey
Clone: CBT3818
Application*: WB, IH, IC, F
Datasheet SDS

PCK2 Matched Antibody Pair (848) (APMAB-848LY)

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Target: PCK2
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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