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Rabbit Anti-PCK2 Recombinant Antibody (D3E11) (CBMAB-P1053-YC)

Provided herein is a Rabbit monoclonal antibody against Human Phosphoenolpyruvate Carboxykinase 2, Mitochondrial. The antibody can be used for immunoassay techniques, such as WB, IP, IF.
See all PCK2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D3E11
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphoenolpyruvate Carboxykinase 2, Mitochondrial
Introduction
PCK2 is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described.
Entrez Gene ID
Human5106
Monkey714922
UniProt ID
HumanQ16822
MonkeyF7E8L8
Alternative Names
Phosphoenolpyruvate Carboxykinase 2, Mitochondrial; EC 4.1.1.32; PEPCK-M; PEPCK2; Phosphoenolpyruvate Carboxykinase [GTP], Mitochondrial; Phosphoenolpyruvate Carboxykinase 2 (Mitochondrial); Phosphopyruvate Carboxylase; PEP Carboxykinase; PEPCK;
Function
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Biological Process
Cellular response to dexamethasone stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to glucose stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to insulin stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to tumor necrosis factorIEA:Ensembl
GluconeogenesisManual Assertion Based On ExperimentIBA:GO_Central
Glycerol biosynthetic process from pyruvateManual Assertion Based On ExperimentIBA:GO_Central
Hepatocyte differentiationManual Assertion Based On ExperimentIBA:GO_Central
NADH oxidationIEA:Ensembl
Oxaloacetate metabolic processIEA:Ensembl
Positive regulation of insulin secretionIEA:Ensembl
Propionate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Response to lipidManual Assertion Based On ExperimentIBA:GO_Central
Response to lipopolysaccharideIEA:Ensembl
Response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrial phosphoenolpyruvate carboxykinase deficiency (M-PEPCKD):
Metabolic disorder resulting from impaired gluconeogenesis. It is a rare disease with less than 10 cases reported in the literature. Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia. Autopsy reveals fatty infiltration of both the liver and kidneys. The disorder is transmitted as an autosomal recessive trait.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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