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Mouse Anti-PCK2 Recombinant Antibody (CBT3818) (V2LY-0625-LY1191)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Monkey
Clone
CBT3818
Antibody Isotype
IgG1
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human PCK2 (AA: 44-175) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Rat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Phosphoenolpyruvate Carboxykinase 2, Mitochondrial
Entrez Gene ID
5106
UniProt ID
Q16822
Function
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Biological Process
Cellular response to dexamethasone stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to glucose stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to insulin stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to tumor necrosis factorIEA:Ensembl
GluconeogenesisManual Assertion Based On ExperimentIBA:GO_Central
Glycerol biosynthetic process from pyruvateManual Assertion Based On ExperimentIBA:GO_Central
Hepatocyte differentiationManual Assertion Based On ExperimentIBA:GO_Central
NADH oxidationIEA:Ensembl
Oxaloacetate metabolic processIEA:Ensembl
Positive regulation of insulin secretionIEA:Ensembl
Propionate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Response to lipidManual Assertion Based On ExperimentIBA:GO_Central
Response to lipopolysaccharideIEA:Ensembl
Response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrial phosphoenolpyruvate carboxykinase deficiency (M-PEPCKD):
Metabolic disorder resulting from impaired gluconeogenesis. It is a rare disease with less than 10 cases reported in the literature. Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia. Autopsy reveals fatty infiltration of both the liver and kidneys. The disorder is transmitted as an autosomal recessive trait.
More Infomation

Xue, S., Cai, Y., Liu, J., Ji, K., Yi, P., Long, H., ... & Song, Y. (2024). Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis. Cellular Signalling, 120, 111198.

Hsu, H. P., Chu, P. Y., Chang, T. M., Huang, K. W., Hung, W. C., Jiang, S. S., ... & Tsai, H. J. (2023). Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor‐positive breast cancer via regulation of the mTOR pathway. Cancer medicine, 12(2), 1588-1601.

Yu, S., Meng, S., Xiang, M., & Ma, H. (2021). Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis. Molecular metabolism, 53, 101257.

Geng, X., Shen, J., Li, F., Yip, J., Guan, L., Rajah, G., ... & Ding, Y. (2021). Phosphoenolpyruvate carboxykinase (PCK) in the brain gluconeogenic pathway contributes to oxidative and lactic injury after stroke. Molecular Neurobiology, 58, 2309-2321.

Dong, H., Feng, Y., Yang, Y., Hu, Y., Jia, Y., Yang, S., ... & Zhao, R. (2021). A novel function of mitochondrial phosphoenolpyruvate carboxykinase as a regulator of inflammatory response in Kupffer cells. Frontiers in Cell and Developmental Biology, 9, 726931.

Li, Z., Liu, X., Zhu, Y., Du, Y., Liu, X., Lv, L., ... & Zhou, Y. (2019). Mitochondrial phosphoenolpyruvate carboxykinase regulates osteogenic differentiation by modulating AMPK/ULK1-dependent autophagy. Stem Cells, 37(12), 1542-1555.

Seenappa, V., Joshi, M. B., & Satyamoorthy, K. (2019). Intricate regulation of phosphoenolpyruvate carboxykinase (PEPCK) isoforms in normal physiology and disease. Current Molecular Medicine, 19(4), 247-272.

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For research use only. Not intended for any clinical use.

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