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PCK2 Matched Antibody Pair (848) (APMAB-848LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-PCK2 polyclonal antibody, 100 ug
Detection Antibody
Anti-PCK2 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
Alternative Names
Phosphoenolpyruvate Carboxykinase 2, Mitochondrial; EC 4.1.1.32; PEPCK-M; PEPCK2; Phosphoenolpyruvate Carboxykinase [GTP], Mitochondrial; Phosphoenolpyruvate Carboxykinase 2 (Mitochondrial); Phosphopyruvate Carboxylase; PEP Carboxykinase; PEPCK;
Entrez Gene ID
5106
UniProt ID
Q16822
More Infomation

Xue, S., Cai, Y., Liu, J., Ji, K., Yi, P., Long, H., ... & Song, Y. (2024). Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis. Cellular Signalling, 120, 111198.

Hsu, H. P., Chu, P. Y., Chang, T. M., Huang, K. W., Hung, W. C., Jiang, S. S., ... & Tsai, H. J. (2023). Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor‐positive breast cancer via regulation of the mTOR pathway. Cancer medicine, 12(2), 1588-1601.

Yu, S., Meng, S., Xiang, M., & Ma, H. (2021). Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis. Molecular metabolism, 53, 101257.

Geng, X., Shen, J., Li, F., Yip, J., Guan, L., Rajah, G., ... & Ding, Y. (2021). Phosphoenolpyruvate carboxykinase (PCK) in the brain gluconeogenic pathway contributes to oxidative and lactic injury after stroke. Molecular Neurobiology, 58, 2309-2321.

Dong, H., Feng, Y., Yang, Y., Hu, Y., Jia, Y., Yang, S., ... & Zhao, R. (2021). A novel function of mitochondrial phosphoenolpyruvate carboxykinase as a regulator of inflammatory response in Kupffer cells. Frontiers in Cell and Developmental Biology, 9, 726931.

Li, Z., Liu, X., Zhu, Y., Du, Y., Liu, X., Lv, L., ... & Zhou, Y. (2019). Mitochondrial phosphoenolpyruvate carboxykinase regulates osteogenic differentiation by modulating AMPK/ULK1-dependent autophagy. Stem Cells, 37(12), 1542-1555.

Seenappa, V., Joshi, M. B., & Satyamoorthy, K. (2019). Intricate regulation of phosphoenolpyruvate carboxykinase (PEPCK) isoforms in normal physiology and disease. Current Molecular Medicine, 19(4), 247-272.

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For research use only. Not intended for any clinical use.

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