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SYN1

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Full Name

synapsin I

Function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.

Biological Process

Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Neuron developmentIEA:Ensembl
Neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of neurotransmitter secretionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Regulation of synaptic vesicle cycleIEA:Ensembl
Regulation of synaptic vesicle exocytosis1 PublicationNAS:ParkinsonsUK-UCL
Synapse organizationIEA:Ensembl
Synaptic vesicle clusteringIEA:Ensembl

Cellular Location

Cell junction, synapse
Golgi apparatus

Involvement in disease

Epilepsy, X-linked, with variable learning disabilities and behavior disorders (EPILX):
A neurologic disorder characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.

PTM

Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.

Anti-SYN1 antibodies

Mouse Anti-SYN1 Recombinant Antibody (CBXS-5861) (CBMAB-S0714-CQ)

SDS

Target: SYN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBXS-5861

Application*: E, WB, IF

Mouse Anti-SYN1 Recombinant Antibody (CBXS-2001) (CBMAB-S4768-CQ)

SDS

Target: SYN1

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBXS-2001

Application*: WB, IP, IF, E

Rabbit Anti-SYN1 Recombinant Antibody (CBXS-2350) (CBMAB-S5109-CQ)

SDS

Target: SYN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXS-2350

Application*: IF, IH, IP, WB

Mouse Anti-SYN1 Recombinant Antibody (CBXS-3230) (CBMAB-S5971-CQ)

SDS

Target: SYN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3230

Application*: E, WB

Rabbit Anti-SYN1 Monoclonal Antibody (E377) (CBMAB-1750-YC)

SDS

Target: SYN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: E377

Application*: IC, IF, DB, WB

Rabbit Anti-SYN1 Recombinant Antibody (CBXS-5334) (CBMAB-S0305-CQ)

SDS

Target: SYN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXS-5334

Application*: IF

Mouse Anti-SYN1 Recombinant Antibody (CBXS-5897) (CBMAB-S0748-CQ)

SDS

Target: SYN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Monkey

Clone: CBXS-5897

Application*: E, WB, P, IF, F

Mouse Anti-SYN1 Recombinant Antibody (CBXS-3957) (CBMAB-S1220-CQ)

SDS

Target: SYN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3957

Application*: E, WB

Mouse Anti-SYN1 Recombinant Antibody (CBXS-4275) (CBMAB-S1523-CQ)

SDS

Target: SYN1

Host: Mouse

Antibody Isotype: IgM

Specificity: Mouse, Rat

Clone: CBXS-4275

Application*: WB

Rabbit Anti-SYN1 Recombinant Antibody (CBXS-5335) (CBMAB-S2548-CQ)

SDS

Target: SYN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXS-5335

Application*: WB, IP

Rabbit Anti-SYN1 Recombinant Antibody (CBXS-0899) (CBMAB-S3818-CQ)

SDS

Target: SYN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-0899

Application*: IF, P, IP, WB

Mouse Anti-SYN1 Recombinant Antibody (CBXS-0900) (CBMAB-S3819-CQ)

SDS

Target: SYN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Mouse, Zebrafish

Clone: CBXS-0900

Application*: IC, IP, E, WB, IH

Mouse Anti-SYN1 Recombinant Antibody (CBXS-0901) (CBMAB-S3820-CQ)

SDS

Target: SYN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-0901

Application*: SE, E, WB

Rabbit Anti-SYN1 Recombinant Antibody (CBXS-0902) (CBMAB-S3821-CQ)

SDS

Target: SYN1

Host: Rabbit

Specificity: Human, Mouse, Rat

Clone: CBXS-0902

Application*: IH, WB

Rabbit Anti-SYN1 Recombinant Antibody (CBXS-0903) (CBMAB-S3822-CQ)

SDS

Target: SYN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXS-0903

Application*: WB, IP, P, IF

Rabbit Anti-SYN1 (Phosphorylated S605) Recombinant Antibody (D4B9I) (PTM-CBMAB-0608LY)

SDS

Target: SYN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D4B9I

Application*: WB

Mouse Anti-SYN1 Recombinant Antibody (4H1) (CBMAB-A8806-LY)

SDS

Target: SYN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4H1

Application*: WB, E

Rabbit Anti-SYN1 Recombinant Antibody (D13C1) (CBMAB-CP2661-LY)

SDS

Target: SYN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D13C1

Application*: WB, IP

Rabbit Anti-SYN1 Monoclonal Antibody (EP2162Y) (CBMAB-1751-YC)

SDS

Target: SYN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EP2162Y

Application*: C, WB

Mouse Anti-SYN1 Recombinant Antibody (CBXS-5515) (CBMAB-S2723-CQ)

SDS

Target: SYN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Mouse

Clone: CBXS-5515

Application*: WB, E, IC

Mouse Anti-SYN1 Recombinant Antibody (CBXS-3068) (CBMAB-S5814-CQ)

SDS

Target: SYN1

Host: Mouse

Specificity: Human

Clone: CBXS-3068

Application*: E, WB

Mouse Anti-SYN1 Recombinant Antibody (CBXS-3084) (CBMAB-S5829-CQ)

SDS

Target: SYN1

Host: Mouse

Specificity: Human

Clone: CBXS-3084

Application*: E, WB

Mouse Anti-SYN1 Recombinant Antibody (CBXS-3142) (CBMAB-S5884-CQ)

SDS

Target: SYN1

Host: Mouse

Specificity: Human

Clone: CBXS-3142

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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