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Rabbit Anti-SYN1 Monoclonal Antibody (E377) (CBMAB-1750-YC)

Provided herein is a rabbit monoclonal antibody against Human SYN1(phospho S553). The antibody, clone E377, can be used for immunoassay techniques, such as ICC, IF, Dot and WB.
See all SYN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
E377
Antibody Isotype
IgG
Application
ICC, IF, Dot, WB

Basic Information

Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser553 of Synapsin (Human)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
synapsin I
Introduction
SYN1 is a member of the synapsin gene family. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. SYN1 serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in SYN1 may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome.
Entrez Gene ID
Human6853
Mouse20964
Rat24949
UniProt ID
HumanP17600
MouseO88935
RatP09951
Alternative Names
SYNI; SYN1a; SYN1b
Function
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Biological Process
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Neuron developmentIEA:Ensembl
Neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of neurotransmitter secretionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Regulation of synaptic vesicle cycleIEA:Ensembl
Regulation of synaptic vesicle exocytosis1 PublicationNAS:ParkinsonsUK-UCL
Synapse organizationIEA:Ensembl
Synaptic vesicle clusteringIEA:Ensembl
Cellular Location
Cell junction, synapse
Golgi apparatus
Involvement in disease
Epilepsy, X-linked, with variable learning disabilities and behavior disorders (EPILX):
A neurologic disorder characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
PTM
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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