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Mouse Anti-SYN1 Recombinant Antibody (4H1) (CBMAB-A8806-LY)

The product is antibody recognizes SYN1. The antibody 4H1 immunoassay techniques such as: WB, ELISA.
See all SYN1 antibodies
Published Data
Fig.1 Immunoblots of PSD95, synapsin I, and NR1 in the SDH of human patients.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4H1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SYN1 (NP_008881, 362 a.a. ~ 450 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
synapsin I
Introduction
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
Entrez Gene ID
6853
UniProt ID
P17600
Alternative Names
SYN1a; SYN1b; SYNI
Function
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Biological Process
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Neuron developmentIEA:Ensembl
Neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of neurotransmitter secretionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Regulation of synaptic vesicle cycleIEA:Ensembl
Regulation of synaptic vesicle exocytosis1 PublicationNAS:ParkinsonsUK-UCL
Synapse organizationIEA:Ensembl
Synaptic vesicle clusteringIEA:Ensembl
Cellular Location
Cell junction, synapse
Golgi apparatus
Involvement in disease
Epilepsy, X-linked, with variable learning disabilities and behavior disorders (EPILX):
A neurologic disorder characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
PTM
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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