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Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490)


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Tested Data
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in WB
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in WB
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in WB
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in WB
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in WB
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in WB
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IF
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IF
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IF
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IF
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IF
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IF
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IF
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IF
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in FC
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in FC
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IHC
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in IHC
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in ELISA
Mouse Anti-SYN1 Recombinant Antibody (CBT3215) (V2LY-0625-LY490) in ELISA

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Monkey, Rat
Clone
CBT3215
Antibody Isotype
IgG1
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human SYN1 (AA: 362-511) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse, Monkey, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
synapsin I
Entrez Gene ID
6853
Function
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Biological Process
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Neuron developmentIEA:Ensembl
Neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of neurotransmitter secretionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Regulation of synaptic vesicle cycleIEA:Ensembl
Regulation of synaptic vesicle exocytosis1 PublicationNAS:ParkinsonsUK-UCL
Synapse organizationIEA:Ensembl
Synaptic vesicle clusteringIEA:Ensembl
Cellular Location
Cell junction, synapse
Golgi apparatus
Involvement in disease
Epilepsy, X-linked, with variable learning disabilities and behavior disorders (EPILX):
A neurologic disorder characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
PTM
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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