TPSAB1

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
Full Name
TPSAB1 Tryptase Alpha/Beta 1
Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).
Biological Process
Biological Process defense response Source:ProtInc1 Publication
Biological Process extracellular matrix disassembly Source:BHF-UCL1 Publication
Biological Process proteolysis Source:ComplexPortal1 Publication
Cellular Location
Secreted
Released from the secretory granules upon mast cell activation.
Involvement in disease
Hereditary alpha tryptasemia is caused by an increase in the copy number (usually between two and three copies) of the alpha allele. Affected individuals have elevated basal serum tryptase levels that are associated with cutaneous flushing and pruritus, dysautonomia, functional gastrointestinal symptoms, chronic pain, and connective tissue abnormalities. It is not clear if the associated multisystem complaints might be due to the coinheritance of a second functional genetic variant.
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Anti-TPSAB1 antibodies

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Mouse Anti-TPSAB1 Recombinant Antibody (CF452) (CBMAB-FT078LY)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF452
Application*: ELISA, IHC, WB
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (2A10-B5) (CBMAB-A9465-LY)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A10-B5
Application*: WB, E
Datasheet SDS

Rat Anti-Tpsab1 Recombinant Antibody (CBYJT-4412) (CBMAB-T3906-YJ)

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Target: Tpsab1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-4412
Application*: WB
Datasheet SDS

Rat Anti-Tpsab1 Recombinant Antibody (CBYJT-4411) (CBMAB-T3905-YJ)

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Target: Tpsab1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-4411
Application*: WB
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4410) (CBMAB-T3904-YJ)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJT-4410
Application*: WB, F, E, IH, IC, IF, P, C
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4409) (CBMAB-T3903-YJ)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Cat, Monkey
Clone: CBYJT-4409
Application*: C, E, P, WB
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4408) (CBMAB-T3902-YJ)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cat, Dog, Monkey, Rat
Clone: CBYJT-4408
Application*: E, C, P, WB
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4407) (CBMAB-T3901-YJ)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4407
Application*: IH
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4406) (CBMAB-T3900-YJ)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4406
Application*: C, P
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4405) (CBMAB-T3899-YJ)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4405
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4404) (CBMAB-T3898-YJ)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4404
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4403) (CBMAB-T3897-YJ)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4403
Application*: WB, IP
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4402) (CBMAB-T3896-YJ)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4402
Application*: P, WB
Datasheet SDS

Rat Tpsab1 ELISA Kit (V2LY-0626-LY865)

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Target: Tpsab1
Sensitivity: 0.022 ng/mL
Detection Range: 0.05-10 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Mouse Tpsab1 ELISA Kit (V2LY-0626-LY1323)

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Target: Tpsab1
Sensitivity: 0.024 ng/mL
Detection Range: 0.05-30 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBT2470) (V2LY-0625-LY1921)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2470
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-TPSAB1 Recombinant Antibody (CBT2775) (V2LY-0625-LY1915)

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Target: TPSAB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: CBT2775
Application*: IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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