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Rat Anti-Tpsab1 Recombinant Antibody (CBYJT-4411) (CBMAB-T3905-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tpsab1 (Tryptase Alpha/Beta 1). The antibody can be used for immunoassay techniques, such as WB.
See all Tpsab1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-4411
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Tryptase beta-1/MCP-7/Mcpt7, Ile29-Phe273, Accession # Q02844
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 29-273

Target

Full Name
TPSAB1 Tryptase Alpha/Beta 1
Introduction
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It may function in innate immunity (By similarity).
Entrez Gene ID
100503895
UniProt ID
Q02844
Alternative Names
Mcp7; Mcp-7; Mcpt7; MMCP-7
Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).
Biological Process
Biological Process defense response Source:ProtInc1 Publication
Biological Process extracellular matrix disassembly Source:BHF-UCL1 Publication
Biological Process proteolysis Source:ComplexPortal1 Publication
Cellular Location
Secreted
Released from the secretory granules upon mast cell activation.
Involvement in disease
Hereditary alpha tryptasemia is caused by an increase in the copy number (usually between two and three copies) of the alpha allele. Affected individuals have elevated basal serum tryptase levels that are associated with cutaneous flushing and pruritus, dysautonomia, functional gastrointestinal symptoms, chronic pain, and connective tissue abnormalities. It is not clear if the associated multisystem complaints might be due to the coinheritance of a second functional genetic variant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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