Rat Anti-Tpsab1 Recombinant Antibody (CBYJT-4411) (CBMAB-T3905-YJ)

Name: Rat Anti-Tpsab1 Recombinant Antibody (CBYJT-4411)
SKU: CBMAB-T3905-YJ
Rating: 5 (1 reviews)

See all Tpsab1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYJT-4411

Application

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse Tryptase beta-1/MCP-7/Mcpt7, Ile29-Phe273, Accession # Q02844

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 29-273

More Infomation

Target

Full Name

TPSAB1 Tryptase Alpha/Beta 1

Introduction

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It may function in innate immunity (By similarity).

Entrez Gene ID

100503895

UniProt ID

Q02844

Alternative Names

Mcp7; Mcp-7; Mcpt7; MMCP-7

Function

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).

Biological Process

Biological Process defense response Source:ProtInc1 Publication
Biological Process extracellular matrix disassembly Source:BHF-UCL1 Publication
Biological Process proteolysis Source:ComplexPortal1 Publication

Cellular Location

Secreted
Released from the secretory granules upon mast cell activation.

Involvement in disease

Hereditary alpha tryptasemia is caused by an increase in the copy number (usually between two and three copies) of the alpha allele. Affected individuals have elevated basal serum tryptase levels that are associated with cutaneous flushing and pruritus, dysautonomia, functional gastrointestinal symptoms, chronic pain, and connective tissue abnormalities. It is not clear if the associated multisystem complaints might be due to the coinheritance of a second functional genetic variant.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rat Anti-Tpsab1 Recombinant Antibody (CBYJT-4411)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4405) (CAT#: CBMAB-T3899-YJ)

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4406) (CAT#: CBMAB-T3900-YJ)

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4407) (CAT#: CBMAB-T3901-YJ)

Mouse Anti-TPSAB1 Recombinant Antibody (CF452) (CAT#: CBMAB-FT078LY)

Mouse Anti-TPSAB1 Recombinant Antibody (CBT2470) (CAT#: V2LY-0625-LY1921)

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4409) (CAT#: CBMAB-T3903-YJ)

Mouse Anti-TPSAB1 Recombinant Antibody (CBT2775) (CAT#: V2LY-0625-LY1915)

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4404) (CAT#: CBMAB-T3898-YJ)

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4410) (CAT#: CBMAB-T3904-YJ)

Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4408) (CAT#: CBMAB-T3902-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry