Mouse Anti-TPSAB1 Recombinant Antibody (CBT2470) (V2LY-0625-LY1921)

Name: Mouse Anti-TPSAB1 Recombinant Antibody (CBT2470)
SKU: V2LY-0625-LY1921
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-TPSAB1 Recombinant Antibody (CBT2470) (V2LY-0625-LY1921) in ELISA

Mouse Anti-TPSAB1 Recombinant Antibody (CBT2470) (V2LY-0625-LY1921) in WB

Mouse Anti-TPSAB1 Recombinant Antibody (CBT2470) (V2LY-0625-LY1921) in IF

Mouse Anti-TPSAB1 Recombinant Antibody (CBT2470) (V2LY-0625-LY1921) in FC

Mouse Anti-TPSAB1 Recombinant Antibody (CBT2470) (V2LY-0625-LY1921) in IHC

Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBT2470

Application

IHC, ICC, FC

Immunogen

Purified recombinant fragment of human TPSAB1 (AA: 31-275) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ICC	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TPSAB1 Tryptase Alpha/Beta 1

Entrez Gene ID

7177

Function

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).

Biological Process

Biological Process defense response Source:ProtInc1 Publication
Biological Process extracellular matrix disassembly Source:BHF-UCL1 Publication
Biological Process proteolysis Source:ComplexPortal1 Publication

Cellular Location

Secreted
Released from the secretory granules upon mast cell activation.

Involvement in disease

Hereditary alpha tryptasemia is caused by an increase in the copy number (usually between two and three copies) of the alpha allele. Affected individuals have elevated basal serum tryptase levels that are associated with cutaneous flushing and pruritus, dysautonomia, functional gastrointestinal symptoms, chronic pain, and connective tissue abnormalities. It is not clear if the associated multisystem complaints might be due to the coinheritance of a second functional genetic variant.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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