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Mouse Anti-TPSAB1 Recombinant Antibody (CBYJT-4402) (CBMAB-T3896-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TPSAB1 (Tryptase Alpha/Beta 1). The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all TPSAB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4402
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 0.2% BSA, 40% Glycerol
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TPSAB1 Tryptase Alpha/Beta 1
Introduction
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to function in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of TPSAB1 exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Entrez Gene ID
7177
UniProt ID
Q15661
Alternative Names
Tryptase Alpha/Beta 1; Tryptase Alpha II; Tryptase Alpha-1; Tryptase Beta I; Tryptase-III; EC 3.4.21.59; Tryptase-I; Tryptase-1; TPSB1; TPS1
Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).
Biological Process
Biological Process defense response Source:ProtInc1 Publication
Biological Process extracellular matrix disassembly Source:BHF-UCL1 Publication
Biological Process proteolysis Source:ComplexPortal1 Publication
Cellular Location
Secreted
Released from the secretory granules upon mast cell activation.
Involvement in disease
Hereditary alpha tryptasemia is caused by an increase in the copy number (usually between two and three copies) of the alpha allele. Affected individuals have elevated basal serum tryptase levels that are associated with cutaneous flushing and pruritus, dysautonomia, functional gastrointestinal symptoms, chronic pain, and connective tissue abnormalities. It is not clear if the associated multisystem complaints might be due to the coinheritance of a second functional genetic variant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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