Mouse Anti-BAX Recombinant Antibody (CBT10) (V2LY-0625-LY3873)

Mouse

Human, Rat, Mouse, Chicken

CBT10

IgG

IF, ICC, WB, IHC-P

Synthetic Peptide of Bax at AA range of 30-110

Mouse

Human, Rat, Mouse, Chicken

IgG

Monoclonal Antibody

Liquid

PBS, Glycerol, BSA

Sodium azide

Batch dependent

> 95% Purity determined by SDS-PAGE.

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

BCL2 Associated X, Apoptosis Regulator

BCL2 Associated X, Apoptosis Regulator; BCL2 Associated X Protein; Bcl-2-Like Protein 4; Bcl2-L-4; BCL2L4; BCL2-Associated X Protein Omega;

Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670).
Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: HGNC-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
Apoptotic mitochondrial changes Source: HGNC-UCL
Apoptotic process Source: DIBU
Apoptotic process involved in blood vessel morphogenesis Source: Ensembl
Apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
Apoptotic signaling pathway Source: HGNC-UCL
B cell apoptotic process Source: HGNC-UCL
B cell homeostasis Source: Ensembl
B cell homeostatic proliferation Source: Ensembl
B cell negative selection Source: Ensembl
B cell receptor apoptotic signaling pathway Source: BHF-UCL
Blood vessel remodeling Source: Ensembl
Cellular response to unfolded protein Source: ParkinsonsUK-UCL
Cellular response to UV Source: Ensembl
Cellular response to virus Source: UniProtKB
Cerebral cortex development Source: Ensembl
Development of secondary sexual characteristics Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Ectopic germ cell programmed cell death Source: Ensembl
Endoplasmic reticulum calcium ion homeostasis Source: UniProtKB
Establishment or maintenance of transmembrane electrochemical gradient Source: HGNC-UCL
Extrinsic apoptotic signaling pathway Source: BHF-UCL
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Fertilization Source: Ensembl
Germ cell development Source: Ensembl
Glycosphingolipid metabolic process Source: Ensembl
Homeostasis of number of cells within a tissue Source: Ensembl
Hypothalamus development Source: Ensembl
Intrinsic apoptotic signaling pathway Source: HGNC-UCL
Intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
Kidney development Source: Ensembl
Mitochondrial fragmentation involved in apoptotic process Source: HGNC-UCL
Mitochondrial fusion Source: HGNC-UCL
Mitochondrion morphogenesis Source: Ensembl
Myeloid cell homeostasis Source: Ensembl
Negative regulation of apoptotic signaling pathway Source: Ensembl
Negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
Negative regulation of fibroblast proliferation Source: Ensembl
Negative regulation of mitochondrial membrane potential Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of peptidyl-serine phosphorylation Source: Ensembl
Negative regulation of protein binding Source: UniProtKB
Neuron apoptotic process Source: Ensembl
Neuron migration Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Ovarian follicle development Source: Ensembl
Positive regulation of apoptotic DNA fragmentation Source: BHF-UCL
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
Positive regulation of B cell apoptotic process Source: Ensembl
Positive regulation of developmental pigmentation Source: Ensembl
Positive regulation of endoplasmic reticulum unfolded protein response Source: UniProtKB
Positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: Reactome
Positive regulation of neuron apoptotic process Source: HGNC-UCL
Positive regulation of protein-containing complex assembly Source: UniProtKB
Positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
Post-embryonic camera-type eye morphogenesis Source: Ensembl
Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
Regulation of apoptotic process Source: UniProtKB
Regulation of mammary gland epithelial cell proliferation Source: Ensembl
Regulation of mitochondrial membrane permeability involved in programmed necrotic cell death Source: Ensembl
Regulation of mitochondrial membrane potential Source: HGNC-UCL
Regulation of nitrogen utilization Source: Ensembl
Regulation of transcription initiation from RNA polymerase II promoter Source: Reactome
Release of cytochrome c from mitochondria Source: UniProtKB
Release of matrix enzymes from mitochondria Source: HGNC-UCL
Response to axon injury Source: Ensembl
Response to gamma radiation Source: Ensembl
Response to salt stress Source: Ensembl
Response to toxic substance Source: HGNC-UCL
Retina development in camera-type eye Source: Ensembl
Retinal cell programmed cell death Source: Ensembl
Sertoli cell proliferation Source: Ensembl
Spermatid differentiation Source: Ensembl
T cell homeostatic proliferation Source: Ensembl
Thymocyte apoptotic process Source: Ensembl
Vagina development Source: Ensembl
Viral process Source: UniProtKB-KW

Isoform Alpha: Cytoplasm; Mitochondrion outer membrane. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. Upon Sendai virus infection, recruited to the mitochondrion through interaction with IRF3 (PubMed:25609812).
Isoform Beta: Cytoplasm
Isoform Gamma: Cytoplasm
Isoform Delta: Cytoplasm

Helical: 172-192 aa